Obesity and fractures.

Melissa Orlandin Premaor, Fabio Vasconcellos Comim, Juliet E Compston
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引用次数: 61

Abstract

Until recently obesity was believed to be protective against fractures. However, a report from a Fracture Liaison Clinic in the UK (2010) reported a surprisingly high proportion of obese postmenopausal women attending the clinic with fractures, and in the GLOW study (2011), a similar prevalence and incidence of fractures in obese and non-obese postmenopausal women was observed. Subsequently, other studies have demonstrated the importance of obesity in the epidemiology of fractures. Obese women are at increased risk of fracture in ankle, leg, humerus, and vertebral column and at lower risk of wrist, hip and pelvis fracture when compared to non-obese women. In men, it has been reported that multiple rib fractures are associated with obesity. Furthermore, falls appear to play an important role in the pathogenesis of fractures in obese subjects. Regarding hip fracture and major fractures, the FRAX algorithm has proven to be a useful predictor in obese individuals. Obese people are less likely to receive bone protective treatment; they have a longer hospital stay and a lower quality of life both before and after fracture. Moreover, the efficacy of antiresorptive therapies is not well established in obese people. The latter is a field for future research.

肥胖和骨折。
直到最近,人们还认为肥胖可以预防骨折。然而,来自英国骨折联络诊所(2010)的一份报告显示,患有骨折的肥胖绝经后妇女在诊所就诊的比例高得惊人,在GLOW研究(2011)中,观察到肥胖和非肥胖绝经后妇女骨折的患病率和发病率相似。随后,其他研究也证明了肥胖在骨折流行病学中的重要性。与非肥胖女性相比,肥胖女性踝关节、腿部、肱骨和脊柱骨折的风险增加,而腕部、髋部和骨盆骨折的风险较低。据报道,在男性中,多处肋骨骨折与肥胖有关。此外,跌倒似乎在肥胖患者骨折的发病机制中起重要作用。关于髋部骨折和主要骨折,FRAX算法已被证明是肥胖个体的有用预测指标。肥胖者接受骨骼保护治疗的可能性较小;他们在骨折前后的住院时间较长,生活质量较低。此外,抗吸收疗法在肥胖人群中的疗效尚未得到很好的证实。后者是未来的研究领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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