Microscopy approaches to investigate protein dynamics and lipid organization.

Q3 Biochemistry, Genetics and Molecular Biology
Molecular Membrane Biology Pub Date : 2014-08-01 Epub Date: 2014-07-21 DOI:10.3109/09687688.2014.937469
Joanna M Kwiatek, Elizabeth Hinde, Katharina Gaus
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引用次数: 7

Abstract

The structure of cell membranes has been intensively investigated and many models and concepts have been proposed for the lateral organization of the plasma membrane. While proteomics and lipidomics have identified many if not all membrane components, how lipids and proteins interactions are coordinated in a specific cell function remains poorly understood. It is generally accepted that the organization of the plasma membrane is likely to play a critical role in the regulation of cell function such as receptor signalling by governing molecular interactions and dynamics. In this review we present different plasma membrane models and discuss microscopy approaches used for investigating protein behaviour, distribution and lipid organization.

显微镜方法研究蛋白质动力学和脂质组织。
细胞膜的结构已被深入研究,许多模型和概念已被提出的横向组织的质膜。虽然蛋白质组学和脂质组学已经确定了许多(如果不是全部的话)膜组分,但脂质和蛋白质在特定细胞功能中的相互作用如何协调仍然知之甚少。人们普遍认为,质膜的组织可能通过控制分子相互作用和动力学在调节细胞功能(如受体信号传导)中发挥关键作用。在这篇综述中,我们提出了不同的质膜模型,并讨论了用于研究蛋白质行为、分布和脂质组织的显微镜方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Molecular Membrane Biology
Molecular Membrane Biology 生物-生化与分子生物学
CiteScore
4.80
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Cessation. Molecular Membrane Biology provides a forum for high quality research that serves to advance knowledge in molecular aspects of biological membrane structure and function. The journal welcomes submissions of original research papers and reviews in the following areas: • Membrane receptors and signalling • Membrane transporters, pores and channels • Synthesis and structure of membrane proteins • Membrane translocation and targeting • Lipid organisation and asymmetry • Model membranes • Membrane trafficking • Cytoskeletal and extracellular membrane interactions • Cell adhesion and intercellular interactions • Molecular dynamics and molecular modelling of membranes. • Antimicrobial peptides.
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