Impact of parental history of myopia on the development of myopia in mainland china school-aged children.

Ophthalmology and eye diseases Pub Date : 2014-06-24 eCollection Date: 2014-01-01 DOI:10.4137/OED.S16031

Lik Thai Lim, Yanhong Gong, Elliott Y Ah-Kee, Gexin Xiao, Xiulan Zhang, Shicheng Yu

{"title":"Impact of parental history of myopia on the development of myopia in mainland china school-aged children.","authors":"Lik Thai Lim, Yanhong Gong, Elliott Y Ah-Kee, Gexin Xiao, Xiulan Zhang, Shicheng Yu","doi":"10.4137/OED.S16031","DOIUrl":null,"url":null,"abstract":"Background: Myopia is a very common condition and a significant public health problem in China. The objective of the study was to explore the genetic influence on myopia in Mainland China school-aged children in Beijing.Methods: In 2008, the data from 15,316 Chinese school students aged 6-18 years from 19 randomized schools in Beijing were analyzed to evaluate genetic influence on myopia in children. Heritability was calculated by mid-parent-offspring regression and parent-offspring regression.Results: The estimate of heritability was 0.30 (95% CI, 0.27-0.33) for refractive value (RV). The adjusted mean refractive error was -2.33D (95% CI, -2.45 to -2.21) in children with two myopic parents compared with -1.13D (95% CI, -1.78 to -1.08) in children with no parental myopia. The adjusted odds ratio (OR) was 2.83 (95% CI, 2.47-3.24) in children with two myopic parents compared with no parental myopia.Conclusion: The study found a strong association between parental history of myopia and genesis of myopia in the offspring even after adjusting for environmental factors.","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"6 ","pages":"31-5"},"PeriodicalIF":0.0000,"publicationDate":"2014-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S16031","citationCount":"31","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Ophthalmology and eye diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4137/OED.S16031","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/1/1 0:00:00","PubModel":"eCollection","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 31

Abstract

Background: Myopia is a very common condition and a significant public health problem in China. The objective of the study was to explore the genetic influence on myopia in Mainland China school-aged children in Beijing.

Methods: In 2008, the data from 15,316 Chinese school students aged 6-18 years from 19 randomized schools in Beijing were analyzed to evaluate genetic influence on myopia in children. Heritability was calculated by mid-parent-offspring regression and parent-offspring regression.

Results: The estimate of heritability was 0.30 (95% CI, 0.27-0.33) for refractive value (RV). The adjusted mean refractive error was -2.33D (95% CI, -2.45 to -2.21) in children with two myopic parents compared with -1.13D (95% CI, -1.78 to -1.08) in children with no parental myopia. The adjusted odds ratio (OR) was 2.83 (95% CI, 2.47-3.24) in children with two myopic parents compared with no parental myopia.

Conclusion: The study found a strong association between parental history of myopia and genesis of myopia in the offspring even after adjusting for environmental factors.

查看原文本刊更多论文

父母近视史对中国大陆学龄儿童近视发展的影响。

背景:近视在中国是一种非常常见的疾病，也是一个重大的公共卫生问题。本研究旨在探讨中国大陆地区北京地区学龄儿童近视的遗传影响。方法:2008年，对北京市19所随机学校的15316名6-18岁中国学生的数据进行分析，评估遗传对儿童近视的影响。采用中间亲代回归和亲代回归计算遗传力。结果:屈光值(RV)的遗传率估计为0.30 (95% CI, 0.27-0.33)。父母双方都近视的儿童校正后的平均屈光误差为-2.33D (95% CI， -2.45 ~ -2.21)，而父母双方都不近视的儿童校正后的平均屈光误差为-1.13D (95% CI， -1.78 ~ -1.08)。父母双方都近视的儿童与父母双方都不近视的儿童的校正优势比(OR)为2.83 (95% CI, 2.47-3.24)。结论:本研究发现，即使在调整了环境因素后，父母近视史与后代近视的发生仍有很强的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Ophthalmology and eye diseases

自引率

0.00%

发文量

审稿时长

8 weeks