TSH reference range in older adults: a Brazilian study.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-06-01 DOI:10.1590/0004-2730000003065

Pedro Weslley Rosario, Maria Regina Calsolari

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引用次数: 9

Abstract

Objective: To establish serum TSH reference values for a population of Brazilian elderly, and to compare them to those found in the adult population.

Subjects and methods: Healthy volunteers aged 70 to 85 years, without known thyroid disease or risk factors for thyroid dysfunction, who did not use any medication that could potentially interfere with TSH, were selected. Subjects with goiter, palpable thyroid nodules, anti-thyroperoxidase antibodies, or altered free T4 were excluded. The sample consisted of 360 older adults (180 per sex).

Results: TSH values corresponding to the 2.5th and 97.5th percentile of the sample were 0.2 and 4.62 mIU/L, respectively. TSH > 2.5 mIU/L was seen in 25.26% of the volunteers, > 3 mIU/L in 15.26%, and > 4 mIU/L in 6.1% of them. TSH values were slightly higher than those previously reported for adults (18-60 years).

Conclusion: This study suggests an upper limit for normal TSH of approximately 4.6 mIU/L for the Brazilian elderly population.

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老年人TSH参考范围:一项巴西研究。

目的:建立巴西老年人血清TSH参考值，并将其与成人人群进行比较。受试者和方法:选择年龄在70 - 85岁之间、无已知甲状腺疾病或甲状腺功能障碍危险因素、未使用任何可能干扰TSH的药物的健康志愿者。排除甲状腺肿、可触及甲状腺结节、抗甲状腺过氧化物酶抗体或游离T4改变的受试者。样本包括360名老年人(男女各180人)。结果:样品第2.5和97.5百分位对应的TSH值分别为0.2和4.62 mIU/L。TSH > 2.5 mIU/L的占25.26%，> 3 mIU/L的占15.26%，> 4 mIU/L的占6.1%。TSH值略高于先前报道的成人(18-60岁)。结论:本研究表明，巴西老年人正常TSH上限约为4.6 mIU/L。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos brasileiros de endocrinologia e metabologia 医学-内分泌学与代谢

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4-8 weeks