Effects of supplementation with omega-3 on insulin sensitivity and non-esterified free fatty acid (NEFA) in type 2 diabetic patients.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-06-01 DOI:10.1590/0004-2730000002861

Payam Farahbakhsh Farsi, Abolghassem Djazayery, Mohammad Reza Eshraghian, Fariba Koohdani, Ali Akbar Saboor-Yaraghi, Hoda Derakhshanian, Mahnaz Zarei, Mohammad Hassan Javanbakht, Mahmoud Djalali

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引用次数: 26

Abstract

Objective: The aim of this study was to determine the role of omega-3 supplementation on NEFA concentration, insulin sensitivity and resistance, and glucose and lipid metabolism in type 2 diabetic patients.

Subjects and methods: Forty-four type 2 diabetic patients were randomly recruited into two groups. Group A received 4 g/day omega-3 soft gels, and group B received a placebo for 10 wks. Blood samples were collected after 12-h fast. Physical activity records, three-day food records, and anthropometric measurements were obtained from all participants at the beginning and end of the study.

Results: Omega-3 supplementation caused a significant reduction in NEFA in the intervention group compared with the placebo group (P = 0.009). Additionally, the administration of omega-3 resulted in significantly greater changes (Diff) for the intervention group in various parameters, such as insulin and Quicki indices compared with the placebo group (P < 0.05).

Conclusions: Omega-3 fatty acid supplementation in type 2 diabetic patients improved insulin sensitivity, probably due to the decrease in NEFA concentrations.

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补充omega-3对2型糖尿病患者胰岛素敏感性和非酯化游离脂肪酸(NEFA)的影响

目的:本研究的目的是确定补充omega-3对2型糖尿病患者NEFA浓度、胰岛素敏感性和抵抗以及糖脂代谢的作用。研究对象和方法:将44例2型糖尿病患者随机分为两组。A组服用4克/天的omega-3软凝胶，B组服用安慰剂10周。禁食12 h后采集血样。在研究开始和结束时，获得了所有参与者的身体活动记录、三天的饮食记录和人体测量数据。结果:与安慰剂组相比，补充Omega-3可显著降低干预组的NEFA (P = 0.009)。此外，与安慰剂组相比，干预组在胰岛素和Quicki指标等各项参数上的变化(Diff)明显更大(P < 0.05)。结论:2型糖尿病患者补充Omega-3脂肪酸可改善胰岛素敏感性，可能是由于NEFA浓度的降低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Arquivos brasileiros de endocrinologia e metabologia 医学-内分泌学与代谢

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4-8 weeks