Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.

Arquivos brasileiros de endocrinologia e metabologia Pub Date : 2014-06-01 DOI:10.1590/0004-2730000003230

Wellington Alves Filho, Renata Regina da Graça Lorencetti Mahmoud, Daniel Marin Ramos, Vergilius José Furtado de Araujo-Filho, Patricia Picciarelli de Lima, Claudio Roberto Cernea, Lenine Garcia Brandão

{"title":"Malignant solitary fibrous tumor of the thyroid: a case-report and review of the literature.","authors":"Wellington Alves Filho, Renata Regina da Graça Lorencetti Mahmoud, Daniel Marin Ramos, Vergilius José Furtado de Araujo-Filho, Patricia Picciarelli de Lima, Claudio Roberto Cernea, Lenine Garcia Brandão","doi":"10.1590/0004-2730000003230","DOIUrl":null,"url":null,"abstract":"<p><p>Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable. </p>","PeriodicalId":8395,"journal":{"name":"Arquivos brasileiros de endocrinologia e metabologia","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1590/0004-2730000003230","citationCount":"9","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Arquivos brasileiros de endocrinologia e metabologia","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1590/0004-2730000003230","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 9

Abstract

Solitary fibrous tumor (SFT) is an uncommon spindle-cell neoplasm that most often involves the pleura, rarely occurring in extra-thoracic locations. Twenty-six cases of SFT arising in the thyroid gland have been described. We report a case of a 60-year-old woman presenting an 8-month history of enlargement of the neck associated with dysphagia. The patient underwent a right hemithyroidectomy and SFT of the thyroid was diagnosed. Immunohistochemistry showed positivity for CD34 marker, and the high number of mitoses and the presence of cellular atypia suggested that the tumor was malignant. To our knowledge, this is the second case of malignant SFT of the thyroid gland ever reported. Due to the rarity of these tumors, the indication of adjuvant therapy and prognosis are uncertain. Long-term follow-up after surgical resection seems to be advisable.

查看原文本刊更多论文

甲状腺恶性孤立性纤维性肿瘤1例报告及文献复习。

孤立性纤维性肿瘤(SFT)是一种罕见的梭形细胞肿瘤，最常累及胸膜，很少发生在胸外部位。本文报道了26例发生于甲状腺的SFT。我们报告一个60岁的妇女的情况下，提出了8个月的历史的颈部扩大与吞咽困难。患者接受了右甲状腺切除术和甲状腺SFT诊断。免疫组化CD34标记物阳性，有丝分裂数高，细胞异型性提示肿瘤为恶性。据我们所知，这是甲状腺恶性SFT的第二例报道。由于这些肿瘤的罕见性，辅助治疗的适应症和预后不确定。手术切除后长期随访似乎是可取的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Arquivos brasileiros de endocrinologia e metabologia 医学-内分泌学与代谢

自引率

0.00%

发文量

审稿时长

4-8 weeks