Sukanya Lodh, Elizabeth A. O'Hare, Norann A. Zaghloul
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引用次数: 40
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Abstract
Primary cilia and their anchoring basal bodies are important regulators of a growing list of signaling pathways. Consequently, dysfunction in proteins associated with these structures results in perturbation of the development and function of a spectrum of tissue and cell types. Here, we review the role of cilia in mediating the development and function of the pancreas. We focus on ciliary regulation of major pathways involved in pancreatic development, including Shh, Wnt, TGF-β, Notch, and fibroblast growth factor. We also discuss pancreatic phenotypes associated with ciliary dysfunction, including pancreatic cysts and defects in glucose homeostasis, and explore the potential role of cilia in such defects. Birth Defects Research (Part C) 102:139–158, 2014. © 2014 Wiley Periodicals, Inc.
原发性纤毛在胰腺发育和疾病中的作用
初级纤毛及其锚定的基底体是越来越多信号通路的重要调节因子。因此,与这些结构相关的蛋白质功能障碍导致一系列组织和细胞类型的发育和功能紊乱。在这里,我们回顾纤毛在调节胰腺发育和功能中的作用。我们关注纤毛调控胰腺发育的主要通路,包括Shh、Wnt、TGF-β、Notch和成纤维细胞生长因子。我们还讨论了与纤毛功能障碍相关的胰腺表型,包括胰腺囊肿和葡萄糖稳态缺陷,并探讨了纤毛在这些缺陷中的潜在作用。出生缺陷研究(C辑)(2):139 - 158,2014。©2014 Wiley期刊公司
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