A study of histopathology of clinically normal appearing skin in the tuberculoid spectrum of leprosy.

Q4 Medicine
Indian journal of leprosy Pub Date : 2013-10-01
M Thomas
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引用次数: 0

Abstract

Histological changes suggestive of leprosy in clinically normal skin have been well documented in the lepromatous spectrum and rarely in the tuberculoid spectrum of the disease. This study attempts to evaluate the histology of clinically normal appearing skin in cases of borderline tuberculoid and tuberculoid leprosy. Biopsies from lesional and a clinically normal appearing skin from newly diagnosed patients with BT or TT leprosy seen in the outpatient department over a period of one year were evaluated by a blinded pathologist. Sixty five patients were included in the study. Six patients had granulomas in the normal skin, six others showed a histological pattern consistent with indeterminate leprosy in the biopsies taken from normal skin. The clinicians must be aware that a small percentage of cases in the TT spectrum also have involvement of normal appearing skin. These patients are at a high risk of under-treatment and may be a cause for paucibacillary relapse. This is a pilot study and a larger sample size is recommended to evaluate the real scenario.

麻风病结核样谱中临床表现正常皮肤的组织病理学研究。
在临床上正常皮肤中提示麻风的组织学变化已在麻风谱中得到充分记录,而在该病的结核样谱中很少有记录。本研究试图评估交界性结核样和结核样麻风病的临床正常皮肤的组织学。一名盲法病理学家对门诊新诊断的BT或TT麻风病患者的病变皮肤和临床表现正常的皮肤活检进行了评估。65名患者参与了这项研究。6例患者在正常皮肤中有肉芽肿,另外6例在正常皮肤活检中表现出与不确定麻风病一致的组织学模式。临床医生必须意识到,在TT谱系中有一小部分病例也涉及正常皮肤。这些患者治疗不足的风险很高,可能是导致少杆菌复发的原因。这是一项初步研究,建议使用更大的样本量来评估真实情况。
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来源期刊
Indian journal of leprosy
Indian journal of leprosy Medicine-Dermatology
CiteScore
0.50
自引率
0.00%
发文量
0
期刊介绍: Indian Journal of Leprosy is one of the oldest journals of India published quarterly by Hind Kusht Nivaran Sangh (Indian Leprosy Association) since 1929. The Journal covers all research aspects of leprosy, tuberculosis and other mycobacterial diseases.
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