Trung N Tran, G Thomas Ray, Michael A Horberg, Barbara P Yawn, Adrienne L Castillo, Patricia Saddier, Laurel A Habel
{"title":"Complications of herpes zoster in cancer patients.","authors":"Trung N Tran, G Thomas Ray, Michael A Horberg, Barbara P Yawn, Adrienne L Castillo, Patricia Saddier, Laurel A Habel","doi":"10.3109/00365548.2014.901554","DOIUrl":null,"url":null,"abstract":"<p><p>Cancer patients tend to have a higher incidence of herpes zoster (HZ), but little is known about their risk of HZ complications. We conducted a retrospective study of 424 newly diagnosed hematologic (HM, n = 140) and solid tumor malignancy (STM, n = 284) patients who developed HZ between January 2001 and December 2006 to measure the frequency and identify risk factors of HZ complications. Patients were adult members of Kaiser Permanente Northern California. HZ diagnosis and complications were confirmed by medical chart review. HM patients with HZ tended to have more HZ complications than STM patients (34% vs 23%, p = 0.02), largely due to more frequent non-pain complications. On multivariate analysis, older age and being male were associated with a higher risk of HZ complications in HM patients; more advanced cancer stage was associated with HZ complications in STM patients. HZ complications are frequent and can present extra disease burden in cancer patients who develop HZ.</p>","PeriodicalId":21541,"journal":{"name":"Scandinavian Journal of Infectious Diseases","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2014-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/00365548.2014.901554","citationCount":"14","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Scandinavian Journal of Infectious Diseases","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3109/00365548.2014.901554","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2014/5/5 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 14
Abstract
Cancer patients tend to have a higher incidence of herpes zoster (HZ), but little is known about their risk of HZ complications. We conducted a retrospective study of 424 newly diagnosed hematologic (HM, n = 140) and solid tumor malignancy (STM, n = 284) patients who developed HZ between January 2001 and December 2006 to measure the frequency and identify risk factors of HZ complications. Patients were adult members of Kaiser Permanente Northern California. HZ diagnosis and complications were confirmed by medical chart review. HM patients with HZ tended to have more HZ complications than STM patients (34% vs 23%, p = 0.02), largely due to more frequent non-pain complications. On multivariate analysis, older age and being male were associated with a higher risk of HZ complications in HM patients; more advanced cancer stage was associated with HZ complications in STM patients. HZ complications are frequent and can present extra disease burden in cancer patients who develop HZ.
癌症患者往往有较高的发病率带状疱疹(HZ),但对其HZ并发症的风险知之甚少。我们对2001年1月至2006年12月间发生HZ的424例新诊断血液病(HM, n = 140)和实体瘤恶性(STM, n = 284)患者进行了回顾性研究,以测量HZ并发症的频率并确定危险因素。患者是北加州凯撒医疗机构的成年会员。通过病历复习确认HZ诊断及并发症。HM合并HZ的患者往往比STM患者有更多的HZ并发症(34% vs 23%, p = 0.02),主要是由于更频繁的非疼痛并发症。在多变量分析中,老年和男性与HM患者HZ并发症的高风险相关;STM患者的HZ并发症与癌症晚期相关。HZ并发症是常见的,并且可以给患有HZ的癌症患者带来额外的疾病负担。