Curcumin.

Q1 Pharmacology, Toxicology and Pharmaceutics

Profiles of drug substances, excipients, and related methodology Pub Date : 2014-01-01 DOI:10.1016/B978-0-12-800173-8.00003-9

Maria L A D Lestari, Gunawan Indrayanto

引用次数: 153

Abstract

Curcumin and its two related compounds, that is, demethoxycurcumin and bis-demethoxycurcumin (curcuminoids) are the main secondary metabolites of Curcuma longa and other Curcuma spp. Curcumin is commonly used as coloring agent as well as food additive; curcumin has also shown some therapeutic activities. This review summarizes stability of curcumin in solutions, spectroscopy characteristics of curcumin (UV, IR, Raman, MS, and NMR), polymorphism forms, method of analysis in both of biological and nonbiological samples, and metabolite studies of curcumin. For analysis of curcumin and its related compounds in complex matrices, application of LC-MS/MS is recommended.

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姜黄素。

姜黄素及其两种相关化合物，即去甲氧基姜黄素和双去甲氧基姜黄素(姜黄素)是姜黄和其他姜黄属植物的主要次生代谢产物，姜黄素常用作着色剂和食品添加剂;姜黄素也显示出一些治疗作用。本文综述了姜黄素在溶液中的稳定性、姜黄素的光谱特征(紫外、红外、拉曼、质谱和核磁共振)、多态性形式、在生物和非生物样品中的分析方法以及姜黄素代谢产物的研究。对于复杂基质中姜黄素及其相关化合物的分析，建议采用LC-MS/MS技术。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Profiles of drug substances, excipients, and related methodology Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

13.10

自引率

0.00%

发文量