Urine β 2-Microglobolin in the Patients with Congenital Heart Disease.

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Noor Mohammad Noori, Simin Sadeghi, Iraj Shahramian, Kambiz Keshavarz
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引用次数: 0

Abstract

Background: This study aimed to evaluate the renal tubular function in the patients with congenital heart disease using β2-microglobulin.

Methods: In this case-control study, based on oxymetry, the patients with congenital heart disease were divided into two groups of cyanotic (n=20) and acyanotic (n=20). Congenital heart disease was diagnosed by echocardiography. Healthy individuals within the same age and sex groups were used as controls. Na(+), β2-micro globulin, creatinine (Cr), and β2-microglobulin/Cr ratio were measured in random urine samples and the results were compared to the same parameters in the control group using Tukey, One-Way ANOVA, and X(2) tests.

Results: Based on the study results, urine sodium in the patients with cyanotic heart disease was significantly different from that of the controls (P=0.023). The results also revealed a significant difference between the two groups with congenital heart disease regarding urine β2-microglobulin (P=0.045). In addition, the patients with cyanotic heart disease were significantly different from those with acyanotic heart disease and the controls regarding urine β2-micro globulin/Cr ratio (P=0.012 and P=0.026, respectively).

Conclusions: The results of this study demonstrated that renal tubular dysfunction began in the patients with congenital heart disease, especially in those with cyanotic congenital heart disease. Besides, early diagnosis before cardiac surgery leads to better control of renal tubular disease.

先天性心脏病患者尿β 2-微珠蛋白的研究
背景:本研究旨在评价β2微球蛋白对先天性心脏病患者肾小管功能的影响。方法:采用病例对照研究方法,根据血氧测定将先天性心脏病患者分为紫绀组(n=20)和无紫绀组(n=20)。通过超声心动图诊断先天性心脏病。同样年龄和性别的健康个体被用作对照。随机测定尿中Na(+)、β2-微球蛋白、肌酐(Cr)和β2-微球蛋白/Cr比值,并采用Tukey检验、单因素方差分析和X(2)检验将结果与对照组相同参数进行比较。结果:研究结果显示,青紫型心脏病患者尿钠与对照组差异有统计学意义(P=0.023)。结果还显示两组先天性心脏病患者尿β2微球蛋白含量差异有统计学意义(P=0.045)。此外,青紫型心脏病患者尿β2-微球蛋白/Cr比值与无青紫型心脏病患者及对照组差异有统计学意义(P=0.012, P=0.026)。结论:本研究结果表明,肾小管功能障碍始于先天性心脏病患者,特别是紫绀型先天性心脏病患者。此外,心脏手术前的早期诊断可以更好地控制肾小管疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Cardiovascular Research Journal
International Cardiovascular Research Journal CARDIAC & CARDIOVASCULAR SYSTEMS-
CiteScore
0.40
自引率
50.00%
发文量
0
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