IL-6 signalling in patients with acute ST-elevation myocardial infarction

Results in immunology Pub Date : 2014-01-01 DOI:10.1016/j.rinim.2013.11.002

Vibeke N. Ritschel , Ingebjørg Seljeflot , Harald Arnesen , Sigrun Halvorsen , Thomas Weiss , Jan Eritsland , Geir Ø Andersen

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引用次数: 60

Abstract

Cytokines of the IL-6 family have been related to infarct size and prognosis in patients with myocardial infarction. The aims of the present study were to elucidate possible associations between myocardial necrosis and left ventricular impairment and members of the IL-6 transsignalling system including soluble (s) IL-6R and (s) glycoprotein 130 (sgp130) in patients with ST-elevation myocardial infarction (STEMI) treated with primary PCI.

In blood samples from 1028 STEMI patients, collected in-hosptial, we found significant correlations between peak TnT and IL-6 and CRP (p < 0.001, all) and between IL-6 and CRP and LV ejection fraction and NT-proBNP (p < 0.001, all). On the contrary, no significant associations were found between peak TnT and sgp130 or sIL-6R. Furthermore sgp130 was significantly elevated in diabetic patients and also associated with the glucometabolic state.

In conclusion, circulating levels of IL-6 and CRP, but not the soluble forms of the receptor (sIL-6R) or the receptor signalling subunit (sgp130) were associated with the extent of myocardial necrosis. The biological importance of the IL-6/gp130-mediated signalling pathways in patients with acute myocardial infarction and dysglycemia should be further elucidated.

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急性st段抬高型心肌梗死患者的IL-6信号传导

IL-6家族细胞因子与心肌梗死患者的梗死面积和预后有关。本研究的目的是阐明心肌坏死和左心室损伤之间的可能关联，以及st段抬高型心肌梗死(STEMI)患者接受初级PCI治疗时IL-6传递信号系统成员，包括可溶性IL-6R和糖蛋白130 (sgp130)。在医院收集的1028例STEMI患者的血液样本中，我们发现TnT、IL-6和CRP峰值之间存在显著相关性(p <0.001，均)，IL-6与CRP、左室射血分数和NT-proBNP之间(p <0.001,所有)。相反，TnT峰值与sgp130或sIL-6R之间没有显著关联。此外，sgp130在糖尿病患者中显著升高，也与糖代谢状态相关。综上所述，IL-6和CRP的循环水平与心肌坏死的程度相关，但与受体的可溶性形式(sIL-6R)或受体信号传导亚基(sgp130)无关。IL-6/gp130介导的信号通路在急性心肌梗死和血糖异常患者中的生物学意义有待进一步阐明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Results in immunology

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