Diagnostic accuracy and prognostic value of the CD64 index in very low birth weight neonates as a marker of early-onset sepsis.

Scandinavian Journal of Infectious Diseases Pub Date : 2014-06-01 Epub Date: 2014-04-02 DOI:10.3109/00365548.2014.896028

Mario Motta, Alice Zini, Antonio Regazzoli, Elena Garzoli, Gaetano Chirico, Luigi Caimi, Marinella Calarco

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引用次数: 12

Abstract

Objective: To assess the diagnostic and prognostic utility of CD64 expression as a marker of early-onset sepsis (EOS) in very low birth weight (VLBW) neonates.

Methods: Neutrophil CD64 expression (CD64 index) was assessed in 129 VLBW neonates within 72 h after birth. The accuracy of the CD64 index in predicting EOS was determined by receiver operating characteristic curve analysis. The relationship between the expression of the CD64 index and neonatal outcomes was evaluated by multivariate analysis.

Results: The highest performance of the CD64 index was achieved at 24 h after birth; accuracy, sensitivity, and negative predictive values were 0.85, 0.89, and 0.99, respectively, with a cut-off value of 2.4. The increased expression of CD64 index was significantly associated with subsequent infections (relative risk 1.54; 95% confidence interval 1.02-2.33).

Conclusions: The CD64 index could be used as a reliable marker of EOS in VLBW neonates and it is an independent risk factor for late-onset infections.

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CD64指数在极低出生体重新生儿中作为早发性败血症标志物的诊断准确性和预后价值

目的:评估CD64表达作为极低出生体重(VLBW)新生儿早发性脓毒症(EOS)的标志物的诊断和预后价值。方法:观察129例VLBW新生儿出生后72h内中性粒细胞CD64的表达(CD64指数)。通过受试者工作特征曲线分析确定CD64指标预测EOS的准确性。通过多因素分析评估CD64指数表达与新生儿结局的关系。结果:CD64指数在出生后24 h达到最高表现;准确性、敏感性和阴性预测值分别为0.85、0.89和0.99，临界值为2.4。CD64指数的表达增加与随后的感染显著相关(相对危险度1.54;95%置信区间1.02-2.33)。结论:CD64指数可作为VLBW新生儿EOS的可靠标志物，是迟发性感染的独立危险因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Scandinavian Journal of Infectious Diseases 医学-传染病学

自引率

0.00%

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审稿时长

4-8 weeks