Control of an outbreak due to orthopedic infections caused by Enterobacteriaceae producing IMP-4 or IMP-8 carbapenemases

Pathologie-biologie Pub Date : 2014-06-01 DOI:10.1016/j.patbio.2014.01.004

F. Pang , X.-Q. Jia , B. Wang , Y.-H. Li , Q.-G. Zhao

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引用次数: 9

Abstract

Objective

To investigate control of an outbreak due to orthopedic infections caused by Enterobacteriaceae producing IMP carbapenemases.

Methods

The sporadic orthopedic infections with Enterobacteriaceae producing carbapenemase (CPE) were retrospectively analyzed in a Chinese tertiary care hospital from November 2010 to September 2012.

Results

The CPE were isolated from four distinct orthopedic patients, three patients infected with Enterobacter cloacae while the other with Klebsiella oxytoca. All strains were resistant to almost all the conventional antimicrobial. The strains produced IMP-4 type detected in the two early patients, while other strains could produce IMP-8 type. All of the four patients had ever undergoing invasive surgical procedure, and three of them were given fluoroquinolones for anti-infection treatment while the other patients was treated with meropenem. Ultimately, all patients were cured and discharged, without outbreak of nosocomial infection caused by CPE.

Conclusion

Our study shows that strict infection control plays an important role in limiting dissemination of Enterobacteriaceae producing IMP carbapenemase. In addition, reasonable supporting treatment and disinfection protection seems to be more effective for the infection of strains.

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控制由产生IMP-4或IMP-8碳青霉烯酶的肠杆菌科引起的骨科感染暴发

目的探讨一起产IMP碳青霉烯酶肠杆菌科致骨科感染的暴发控制。方法回顾性分析2010年11月至2012年9月某三级医院散发性产碳青霉烯酶肠杆菌科(enterobacteraceae, CPE)骨科感染病例。结果从4例不同类型的骨科患者中分离出CPE，其中3例为阴沟肠杆菌感染，1例为产氧克雷伯菌感染。所有菌株对几乎所有常规抗菌素都具有耐药性。在两例早期患者中检测到的菌株产生IMP-4型，其他菌株产生IMP-8型。4例患者均曾接受有创手术，其中3例给予氟喹诺酮类抗感染治疗，其余患者给予美罗培南治疗。最终，所有患者均治愈出院，未发生CPE引起的院内感染。结论严格的感染控制对抑制产IMP碳青霉烯酶肠杆菌科细菌的传播具有重要作用。此外，合理的辅助治疗和消毒保护似乎对菌株感染更有效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathologie-biologie 医学-病理学

自引率

0.00%

发文量

审稿时长

6-12 weeks