Cardiovascular effects of mild hypothermia in post-cardiac arrest patients by beat-to-beat monitoring. A single centre pilot study.

Acute cardiac care Pub Date : 2014-06-01 Epub Date: 2014-03-21 DOI:10.3109/17482941.2014.889310
Chiara Lazzeri, Andrea Sori, Pasquale Bernardo, Marco Chiostri, Eleonora Tommasi, Mery Zucchini, Salvatore Mario Romano, Gian Franco Gensini, Serafina Valente
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引用次数: 1

Abstract

Background: Data on the hemodynamic and cardiovascular effects of hypothermia in patients with cardiac arrest are scarce. The aim of this study was to evaluate the hemodynamic changes induced by hypothermia by means of Most Care(®) (pressure recording analytical method, PRAM methodology), a beat-to-beat hemodynamic monitoring method.

Methods: We enrolled 20 patients with cardiac arrest (CA) consecutively admitted to our intensive cardiac care unit and treated with mild hypothermia (TH).

Results: While non-survivors showed no changes in haemodynamic variables throughout the study period, survivors exhibited a significant increase in systemic vascular resistance indexed during hypothermia and a trend towards lower values of heart rate and higher levels of mean arterial pressure.

Conclusions: According to our data, PRAM methodology proved to be a feasible and clinically useful tool in CA patients treated with TH since it provides continuous beat-to-beat haemodynamic monitoring that is based on assessment of several haemodynamic variables. Moreover, we observed that survivors showed a different haemodynamic behaviour during hypothermia in respect to patients who died. However, further studies, performed in larger cohorts, are needed to better elucidate the haemodynamic effects of hypothermia in CA patients by means of PRAM methodology.

通过逐拍监测心脏骤停后患者的亚低温对心血管的影响单中心试点研究。
背景:关于心脏骤停患者低温对血液动力学和心血管影响的数据很少。本研究的目的是通过Most Care(®)(压力记录分析方法,PRAM方法学),一种逐拍血流动力学监测方法来评估低体温引起的血流动力学变化。方法:我们招募了20例心脏骤停(CA)患者,他们连续入住我们的心脏重症监护室,并接受了亚低温治疗。结果:虽然非幸存者在整个研究期间血流动力学变量没有变化,但幸存者在低温期间表现出系统性血管阻力指数的显著增加,并且有降低心率和提高平均动脉压水平的趋势。结论:根据我们的数据,PRAM方法在接受TH治疗的CA患者中被证明是一种可行且临床上有用的工具,因为它提供了基于几个血流动力学变量评估的连续搏动血流动力学监测。此外,我们观察到幸存者在低温期间表现出与死亡患者不同的血流动力学行为。然而,需要在更大的队列中进行进一步的研究,以更好地阐明通过PRAM方法降低体温对CA患者的血流动力学影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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