Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer.

Q Medicine

癌症 Pub Date : 2014-03-01 DOI:10.5732/cjc.013.10243

John M Pawelek

引用次数: 32

Abstract

This perspective article highlights the leukocyte-cancer cell hybrid theory as a mechanism for cancer metastasis. Beginning from the first proposal of the theory more than a century ago and continuing today with the first proof for this theory in a human cancer, the hybrid theory offers a unifying explanation for metastasis. In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome.

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骨髓来源的细胞与癌细胞的融合:转移作为癌症的继发性疾病。

这篇前瞻性文章强调了白细胞-癌细胞杂交理论作为癌症转移的机制。从一个多世纪前该理论的首次提出，到今天该理论在人类癌症中的首次证明，混合理论为转移提供了一个统一的解释。在这种情况下，白细胞与癌细胞的融合是叠加在早期肿瘤上的继发性疾病，产生一个具有白细胞-癌细胞混合表观基因组的新的恶性细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

癌症 ONCOLOGY-

CiteScore

3.47

自引率

0.00%

发文量

9010

审稿时长

12 weeks

期刊介绍： In July 2008, Landes Bioscience and Sun Yat-sen University Cancer Center began co-publishing the international, English-language version of AI ZHENG or the Chinese Journal of Cancer (CJC). CJC publishes original research, reviews, extra views, perspectives, supplements, and spotlights in all areas of cancer research. The primary criteria for publication in CJC are originality, outstanding scientific merit, and general interest. The Editorial Board is composed of members from around the world, who will strive to maintain the highest standards for excellence in order to generate a valuable resource for an international readership.