Magnetic and optical properties of multifunctional core-shell radioluminescence nanoparticles.

Hongyu Chen, Daniel C Colvin, Bin Qi, Thomas Moore, Jian He, O Thompson Mefford, Frank Alexis, John C Gore, Jeffrey N Anker
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Abstract

When X-rays irradiate radioluminescence nanoparticles, they generate visible and near infrared light that can penetrate through centimeters of tissue. X-ray luminescence tomography (XLT) maps the location of these radioluminescent contrast agents at high resolution by scanning a narrow X-ray beam through the tissue sample and collecting the luminescence at every position. Adding magnetic functionality to these radioluminescent particles would enable them to be guided, oriented, and heated using external magnetic fields, while their location and spectrum could be imaged with XLT and complementary magnetic resonance imaging. In this work, multifunctional monodispersed magnetic radioluminescent nanoparticles were developed as potential drug delivery carriers and radioluminescence imaging agents. The particles consisted of a spindle-shaped magnetic γ-Fe2O3 core and a radioluminescent europium-doped gadolinium oxide shell. Particles with solid iron oxide cores displayed saturation magnetizations consistent with their ~13% core volume, however, the iron oxide quenched their luminescence. In order to increase the luminescence, we partially etched the iron oxide core in oxalic acid while preserving the radioluminescent shell. The core size was controlled by the etching time which in turn affected the particles' luminescence and magnetic properties. Particles with intermediate core sizes displayed both strong magnetophoresis and luminescence properties. They also served as MRI contrast agents with relaxivities of up to 58 mM-1s-1 (r2) and 120 mM-1s-1 (r2*). These particles offer promising multimodal MRI/fluorescence/X-ray luminescence contrast agents. Our core-shell synthesis technique offers a flexible method to control particle size, shape, and composition for a wide range of biological applications of magnetic/luminescent nanoparticles.

多功能核壳放射纳米粒子的磁学和光学特性。
当 X 射线照射放射发光纳米粒子时,它们会产生可见光和近红外线,这种光可以穿透几厘米厚的组织。X 射线发光断层扫描(XLT)通过扫描穿过组织样本的窄 X 射线束,收集每个位置的发光情况,从而以高分辨率绘制出这些放射性发光造影剂的位置图。为这些放射性发光粒子添加磁性功能后,就能利用外部磁场对它们进行引导、定向和加热,同时利用 XLT 和互补磁共振成像技术对它们的位置和光谱进行成像。这项研究开发了多功能单分散磁性辐射纳米粒子,作为潜在的药物输送载体和辐射成像剂。这些颗粒由纺锤形磁性 γ-Fe2O3 内核和掺杂铕的放射性氧化钆外壳组成。具有固体氧化铁内核的颗粒显示出与其约 13% 的内核体积相一致的饱和磁化,但氧化铁淬灭了它们的发光。为了增加发光,我们在草酸中部分蚀刻了氧化铁内核,同时保留了放射性发光外壳。内核大小受蚀刻时间的控制,而蚀刻时间又会影响颗粒的发光和磁性。具有中等内核尺寸的微粒显示出很强的磁性和发光特性。它们还可用作磁共振成像对比剂,弛豫度高达 58 mM-1s-1 (r2) 和 120 mM-1s-1 (r2*)。这些颗粒是很有前景的多模式核磁共振成像/荧光/X 射线发光对比剂。我们的核壳合成技术提供了一种灵活的方法来控制颗粒的大小、形状和成分,从而实现磁性/发光纳米颗粒的广泛生物应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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1.5 months
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