Verline Justilien, Alan P. Fields
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引用次数: 23
Abstract
Lung cancer is a leading cause of cancer deaths worldwide. Despite advances in chemotherapy, radiation therapy, and surgery, lung cancer continues to have a low 5-year survival rate, highlighting a dire need for more effective means of prevention, diagnosis, prognosis, and treatment. Mouse models that recapitulate the clinical features of advanced human lung cancer are critical for testing novel therapeutic approaches. This unit describes a highly reproducible, easy-to-establish orthotopic murine model of lung cancer, provides methods for in vivo imaging and monitoring of tumor growth, and discusses the usefulness of this model for translational lung cancer research and the development of therapeutic strategies. Curr. Protoc. Pharmacol. 62:14.27.1-14.27.17. © 2013 by John Wiley & Sons, Inc.
人类非小细胞肺癌(NSCLC)原位模型在评估新型和新兴癌症治疗方法中的效用和应用
肺癌是全球癌症死亡的主要原因。尽管在化疗、放射治疗和手术方面取得了进展，但肺癌的5年生存率仍然很低，这表明迫切需要更有效的预防、诊断、预后和治疗手段。概括晚期人类肺癌临床特征的小鼠模型对于测试新的治疗方法至关重要。本单元描述了一种高度可重复、易于建立的原位肺癌小鼠模型，提供了体内成像和肿瘤生长监测的方法，并讨论了该模型在转化肺癌研究和治疗策略开发中的有用性。咕咕叫。Protoc。杂志,62:14.27.1-14.27.17。©2013 by John Wiley &儿子,Inc。
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