Phenotypic and environmental factors associated with elevated autoantibodies at clinical onset of paediatric type 1 diabetes mellitus

Results in immunology Pub Date : 2012-01-01 Epub Date: 2012-06-29 DOI:10.1016/j.rinim.2012.06.002

Anne-Louise Ponsonby , Angela Pezic , Fergus J. Cameron , Christine Rodda , Justine A. Ellis , Andrew S. Kemp , John Carlin , Terence Dwyer

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引用次数: 7

Abstract

To examine possible determinants of autoantibody levels at type 1 diabetes mellitus (T1DM) onset.

We assessed levels of glutamic acid decarboxylase 65 islet cell antigen (GADA) and anti-insulin antibodies (IAA) in 247 incident T1DM cases presenting <15 years of age in Melbourne from 1st March 2008 to 30th June 2010.

58.9% (142/241) of cases were GADA seropositive and 42.3% (94/222) were IAA seropositive. Factors associated with elevated IAA antibodies included younger age and red hair phenotype. Factors associated with elevated GAD antibodies included lower birthweight and recent eczema. Intriguingly, low recent or past sun exposure was only associated with elevated GADA levels among children presenting at age <5 years, not older (difference in effect, p<0.05 for 4 of 5 associations).

These findings show that environmental and phenotypic factors are associated with autoantibody levels at time of presentation for T1DM. We recommend such environmental and phenoytypic factors should be examined in further detail.

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表型和环境因素与儿童1型糖尿病临床发病时自身抗体升高相关

探讨1型糖尿病(T1DM)发病时自身抗体水平的可能决定因素。我们评估了2008年3月1日至2010年6月30日在墨尔本发生的247例15岁T1DM患者的谷氨酸脱羧酶65胰岛细胞抗原(GADA)和抗胰岛素抗体(IAA)水平，其中58.9%(142/241)的患者GADA血清呈阳性，42.3%(94/222)的患者IAA血清呈阳性。与IAA抗体升高相关的因素包括年轻和红发表型。与GAD抗体升高相关的因素包括低出生体重和近期湿疹。有趣的是，在5岁的儿童中，最近或过去的低阳光照射仅与GADA水平升高有关，而与更大的儿童无关(效果差异，5个关联中有4个为0.05)。这些发现表明，环境和表型因素与T1DM表现时的自身抗体水平相关。我们建议对这些环境和表型因素进行更详细的检查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Results in immunology

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