Impact of Growth Hormone on Cystatin C.

Nephron Extra Pub Date : 2013-11-20 eCollection Date: 2013-01-01 DOI:10.1159/000356464

Lisa Sze, René L Bernays, Cornelia Zwimpfer, Peter Wiesli, Michael Brändle, Christoph Schmid

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引用次数: 12

Abstract

Background: Cystatin C (CysC) is an alternative marker to creatinine for estimation of the glomerular filtration rate (GFR). Hormones such as thyroid hormones and glucocorticoids are known to have an impact on CysC. In this study, we examined the effect of growth hormone (GH) on CysC in patients with acromegaly undergoing transsphenoidal surgery.

Methods: Creatinine, CysC, GH and insulin-like growth factor-1 (IGF-1) were determined in 24 patients with acromegaly before and following transsphenoidal surgery. Estimated GFR was calculated using the Chronic Kidney Disease Epidemiology Collaboration formula.

Results: In all patients, surgical debulking resulted in decreased clinical disease activity and declining GH/IGF-1 levels. Postoperatively, biochemical cure was documented in 20 out of 24 patients. Creatinine levels (mean ± SEM) increased from 72 ± 3 to 80 ± 3 µmol/l (p = 0.0004) and concurrently, estimated GFR decreased from 99 ± 3 to 91 ± 3 ml/min (p = 0.0008). In contrast to creatinine, CysC levels decreased from 0.72 ± 0.02 to 0.68 ± 0.02 mg/l (p = 0.0008).

Conclusions: Our study provides strong evidence for discordant effects of GH on creatinine and CysC in patients with acromegaly undergoing transsphenoidal surgery, thus identifying another hormone that influences CysC independent of renal function.

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生长激素对胱抑素C的影响。

背景:胱抑素C (CysC)是评估肾小球滤过率(GFR)的替代指标，可替代肌酐。众所周知，甲状腺激素和糖皮质激素等激素对CysC有影响。在这项研究中，我们研究了生长激素(GH)对经蝶窦手术的肢端肥大症患者CysC的影响。方法:测定24例肢端肥大症患者经蝶窦手术前后的肌酐、CysC、GH和胰岛素样生长因子-1 (IGF-1)水平。估计GFR使用慢性肾脏疾病流行病学协作公式计算。结果:在所有患者中，手术减体积导致临床疾病活动性降低和GH/IGF-1水平下降。术后24例患者中有20例生化治愈。肌酐水平(平均±SEM)从72±3µmol/l增加到80±3µmol/l (p = 0.0004)，同时，估计GFR从99±3下降到91±3 ml/min (p = 0.0008)。与肌酐相比，CysC水平从0.72±0.02 mg/l降至0.68±0.02 mg/l (p = 0.0008)。结论:我们的研究提供了强有力的证据，证明GH对经蝶窦手术肢端肥大症患者肌酐和CysC的影响不一致，从而确定了另一种独立于肾功能影响CysC的激素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron Extra

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.