{"title":"Possible impact of factor V Leiden genotype on warfarin induced bleeding.","authors":"Tejasvita Gaikwad, Kanjaksha Ghosh, Shrimati Shetty","doi":"10.4103/0971-6866.120807","DOIUrl":null,"url":null,"abstract":"We read with interest the report, recently published by Nahar et al.[1] on the prevalence of warfarin sensitive alleles in factor V Leiden (FVL) mutation carriers. The study provides preliminary evidence for the need of pre‐prescription genotyping of warfarin sensitive polymorphisms (CYP2C9*2, *3 and Vitamin‐K epoxide reductase complex subunit1 [VKORC1]‐1639G/A) in patients who are at risk of thrombosis (carriers of thrombophilic marker) and require anticoagulation therapy.","PeriodicalId":88516,"journal":{"name":"Indian journal of human genetics","volume":"19 3","pages":"377-8"},"PeriodicalIF":0.0000,"publicationDate":"2013-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4103/0971-6866.120807","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian journal of human genetics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/0971-6866.120807","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
We read with interest the report, recently published by Nahar et al.[1] on the prevalence of warfarin sensitive alleles in factor V Leiden (FVL) mutation carriers. The study provides preliminary evidence for the need of pre‐prescription genotyping of warfarin sensitive polymorphisms (CYP2C9*2, *3 and Vitamin‐K epoxide reductase complex subunit1 [VKORC1]‐1639G/A) in patients who are at risk of thrombosis (carriers of thrombophilic marker) and require anticoagulation therapy.
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