Nesfatin-1 in childhood and adolescent obesity and its association with food intake, body composition and insulin resistance

Regulatory Peptides Pub Date : 2014-01-10 DOI:10.1016/j.regpep.2013.12.001

Ghada M. Anwar , Gamal Yamamah , Amani Ibrahim , Dalia El-Lebedy , Tarek M. Farid , Rasha Mahmoud

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引用次数: 46

Abstract

Nesfatin-1 is an anorexigenic peptide that controls feeding behavior and glucose homeostasis. However, there is little data that exists regarding nesfatin-1 secretion in obese children and young adolescents. The aim of this study is to investigate serum nesfatin-1 in childhood and adolescent obesity and to study potential correlations with food intake, anthropometric indices, body composition and insulin resistance. Forty obese children and adolescents and 40 healthy control subjects were studied. Anthropometric measurements were assessed, dietary food intake was evaluated based on 3-days food record and body composition indices were evaluated using bioelectrical impedance analysis. Lipid profile, fasting blood sugar, fasting insulin and HOMA-IR were measured. Fasting serum nesfatin-1 was quantitatively assayed by ELISA. Serum nesfatin-1 was significantly higher in obese group (2.49 ± 1.96 ng/ml) than in control group (0.70 ± 0.81 ng/ml), P = 0.001. Positive correlations with serum insulin (P = 0.001), HOMA-IR (P = 0.000), BMI-SDS (P = 0.04), body fat % (P = 0.000), fat mass (P = 0.000), fat free mass (P = 0.03), CHO % (P = 0.000), and saturated fat % (P = 0.01) were found. While significant negative correlation with protein % (P = 0.000) was observed. In conclusion, our results denote that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of insulin resistance in obese children and young adolescents.

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Nesfatin-1在儿童和青少年肥胖中的作用及其与食物摄入、身体成分和胰岛素抵抗的关系

Nesfatin-1是一种控制摄食行为和葡萄糖稳态的无氧肽。然而，关于肥胖儿童和青少年中nesfatin-1分泌的数据很少。本研究的目的是研究儿童和青少年肥胖的血清nesfatin-1，并研究其与食物摄入、人体测量指标、身体成分和胰岛素抵抗的潜在相关性。研究对象为40名肥胖儿童和青少年及40名健康对照者。测量人体测量值，根据3 d进食记录评估膳食摄取量，利用生物电阻抗分析评估体成分指数。测定血脂、空腹血糖、空腹胰岛素和HOMA-IR。ELISA法测定空腹血清nesfatin-1含量。肥胖组血清nesfatin-1(2.49±1.96 ng/ml)显著高于对照组(0.70±0.81 ng/ml)， P = 0.001。与血清胰岛素(P = 0.001)、HOMA-IR (P = 0.000)、BMI-SDS (P = 0.04)、体脂% (P = 0.000)、脂肪质量(P = 0.000)、无脂质量(P = 0.03)、CHO % (P = 0.000)、饱和脂肪% (P = 0.01)呈正相关。与蛋白%呈显著负相关(P = 0.000)。综上所述，我们的研究结果表明，nesfatin-1可能在肥胖儿童和青少年的食物摄入调节和胰岛素抵抗的发病机制中发挥重要作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Peptides 医学-内分泌学与代谢

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审稿时长

2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.

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