Circulating cytokines and histological liver damage in chronic hepatitis B infection.

Hepatitis research and treatment Pub Date : 2013-01-01 Epub Date: 2013-10-31 DOI:10.1155/2013/757246
Kittiyod Poovorawan, Pisit Tangkijvanich, Chintana Chirathaworn, Naruemon Wisedopas, Sombat Treeprasertsuk, Piyawat Komolmit, Yong Poovorawan
{"title":"Circulating cytokines and histological liver damage in chronic hepatitis B infection.","authors":"Kittiyod Poovorawan,&nbsp;Pisit Tangkijvanich,&nbsp;Chintana Chirathaworn,&nbsp;Naruemon Wisedopas,&nbsp;Sombat Treeprasertsuk,&nbsp;Piyawat Komolmit,&nbsp;Yong Poovorawan","doi":"10.1155/2013/757246","DOIUrl":null,"url":null,"abstract":"<p><p>Each phase of hepatitis B infection stimulates distinct viral kinetics and host immune responses resulting in liver damage and hepatic fibrosis. Our objective has been to correlate host inflammatory immune response including circulating Th1 and Th2 cytokines in patients with chronic hepatitis B infection with liver histopathology. Sixty-four patients with chronic hepatitis B without previous treatment were recruited. The liver histology and histological activity index were assessed for various degrees of necroinflammation and hepatic fibrosis. We determined circulating levels of the Th1 and Th2 cytokines. Forty-six males and 18 females at a median age of 34.5 years were studied. HBeAg was present in 28/64 (43.75%) of the patients. In patients negative for HBeAg, IL-10 and IFN-gamma were significantly correlated with degrees of necroinflammation (r = 0.34, r = 0.38, resp.; P < 0.05). Moreover, TNF-alpha was significantly correlated with degrees of fibrosis (r = 0.35; P < 0.05), and IL-10 and TNF-alpha were significantly correlated with significant fibrosis (r = 0.39, r = 0.35, resp.; P < 0.05). These correlations were found in the HBeAg negative group as opposed to the HBeAg positive group. In HBeAg negative patients, circulating cytokines IL-10 and IFN-gamma were correlated with degrees of necroinflammation, whereas IL-10 and TNF-alpha were correlated with significant fibrosis. </p>","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2013 ","pages":"757246"},"PeriodicalIF":0.0000,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/757246","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hepatitis research and treatment","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2013/757246","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2013/10/31 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 16

Abstract

Each phase of hepatitis B infection stimulates distinct viral kinetics and host immune responses resulting in liver damage and hepatic fibrosis. Our objective has been to correlate host inflammatory immune response including circulating Th1 and Th2 cytokines in patients with chronic hepatitis B infection with liver histopathology. Sixty-four patients with chronic hepatitis B without previous treatment were recruited. The liver histology and histological activity index were assessed for various degrees of necroinflammation and hepatic fibrosis. We determined circulating levels of the Th1 and Th2 cytokines. Forty-six males and 18 females at a median age of 34.5 years were studied. HBeAg was present in 28/64 (43.75%) of the patients. In patients negative for HBeAg, IL-10 and IFN-gamma were significantly correlated with degrees of necroinflammation (r = 0.34, r = 0.38, resp.; P < 0.05). Moreover, TNF-alpha was significantly correlated with degrees of fibrosis (r = 0.35; P < 0.05), and IL-10 and TNF-alpha were significantly correlated with significant fibrosis (r = 0.39, r = 0.35, resp.; P < 0.05). These correlations were found in the HBeAg negative group as opposed to the HBeAg positive group. In HBeAg negative patients, circulating cytokines IL-10 and IFN-gamma were correlated with degrees of necroinflammation, whereas IL-10 and TNF-alpha were correlated with significant fibrosis.

Abstract Image

Abstract Image

慢性乙型肝炎感染的循环细胞因子和组织学肝损伤。
乙型肝炎感染的每个阶段刺激不同的病毒动力学和宿主免疫反应,导致肝损伤和肝纤维化。我们的目的是将慢性乙型肝炎感染患者的宿主炎症免疫反应(包括循环Th1和Th2细胞因子)与肝脏组织病理学联系起来。64名既往未接受治疗的慢性乙型肝炎患者被纳入研究。评估不同程度的坏死、炎症和肝纤维化的肝脏组织学和组织学活性指数。我们测定了循环中Th1和Th2细胞因子的水平。研究对象为46名男性和18名女性,平均年龄为34.5岁。64例患者中有28例(43.75%)存在HBeAg。在HBeAg阴性的患者中,IL-10和ifn - γ与坏死性炎症程度显著相关(r = 0.34, r = 0.38, p < 0.05)。P < 0.05)。此外,tnf - α与纤维化程度显著相关(r = 0.35;P < 0.05), IL-10、tnf - α与显著纤维化显著相关(r = 0.39, r = 0.35, P < 0.05);P < 0.05)。这些相关性在HBeAg阴性组与HBeAg阳性组中被发现。在HBeAg阴性患者中,循环细胞因子IL-10和ifn - γ与坏死炎症程度相关,而IL-10和tnf - α与显著纤维化相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信