A 1:2 cocrystal of genistein with isonicotinamide: crystal structure and Hirshfeld surface analysis.

IF 0.8 4区化学

Acta crystallographica. Section C, Crystal structure communications Pub Date : 2013-11-01 Epub Date: 2013-10-31 DOI:10.1107/S0108270113029545

Michał Sowa, Katarzyna Slepokura, Ewa Matczak-Jon

引用次数: 25

Abstract

Genistein, a naturally occurring polyphenolic compound, was combined with isonicotinamide, a pharmaceutically acceptable coformer, to yield a 1:2 cocrystal [systematic name: 5,7-dihydroxy-3-(4-hydroxyphenyl)chromen-4-one-pyridine-4-carboxamide (1/2)], C15H10O5·2C6H6N2O. The molecules in the cocrystalline phase are present in their neutral forms, and assemble a molecular layer by means of hydrogen bonding.

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染料木黄酮与异烟酰胺的1:2共晶:晶体结构及赫氏表面分析。

染料木黄酮是一种天然存在的多酚类化合物，与异烟酰胺(一种药学上可接受的共构体)结合，生成1:2的共晶[系统名称:5,7-二羟基-3-(4-羟基苯基)铬-4- 1 -吡啶-4-羧酰胺(1/2)]C15H10O5·2C6H6N2O。共晶相的分子以中性形式存在，通过氢键形成分子层。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta crystallographica. Section C, Crystal structure communications 化学-晶体学

自引率

12.50%

发文量

审稿时长

1 months

期刊介绍： Acta Crystallographica Section C: Structural Chemistry is continuing its transition to a journal that publishes exciting science with structural content, in particular, important results relating to the chemical sciences. Section C is the journal of choice for the rapid publication of articles that highlight interesting research facilitated by the determination, calculation or analysis of structures of any type, other than macromolecular structures. Articles that emphasize the science and the outcomes that were enabled by the study are particularly welcomed. Authors are encouraged to include mainstream science in their papers, thereby producing manuscripts that are substantial scientific well-rounded contributions that appeal to a broad community of readers and increase the profile of the authors.