Electron paramagnetic resonance study of tumor affected bone marrow.

Q2 Medicine

Cancer Microenvironment Pub Date : 2013-12-01 Epub Date: 2013-09-18 DOI:10.1007/s12307-013-0137-z

A P Burlaka, I I Ganusevich, M R Gafurov, S N Lukin, E P Sidorik

引用次数: 14

Abstract

To study the mechanism of interaction of tumor cells with bone marrow cells continuous wave electron paramagnetic resonance (EPR) experiments at 9 GHz including a spin trapping of superoxide were carried out. The common features of the EPR spectra in healthy and tumor affected tissues of donors and rats as well as their difference are presented and discussed. It is proposed that labile iron pool plays a significant role in mechanisms of tumor invasion. We hope that the observed EPR features could be used to study the mechanisms of invasion and progression of tumor in different organs.

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电子顺磁共振研究受累骨髓肿瘤。

为了研究肿瘤细胞与骨髓细胞相互作用的机制，在9 GHz下进行了包含超氧化物自旋捕获的连续波电子顺磁共振(EPR)实验。本文介绍并讨论了供体健康组织和肿瘤组织及大鼠EPR谱的共同特征及其差异。不稳定铁池在肿瘤侵袭机制中起重要作用。我们希望观察到的EPR特征可以用于研究肿瘤在不同器官的侵袭和进展机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Microenvironment Medicine-Oncology

CiteScore

4.90

自引率

0.00%

发文量

期刊介绍： Cancer Microenvironment is the official journal of the International Cancer Microenvironment Society (ICMS). It publishes original studies in all aspects of basic, clinical and translational research devoted to the study of cancer microenvironment. It also features reports on clinical trials. Coverage in Cancer Microenvironment includes: regulation of gene expression in the cancer microenvironment; innate and adaptive immunity in the cancer microenvironment, inflammation and cancer; tumor-associated stroma and extracellular matrix, tumor-endothelium interactions (angiogenesis, extravasation), cancer stem cells, the metastatic niche, targeting the tumor microenvironment: preclinical and clinical trials.