Hepatitis C as a prognostic indicator among noncirrhotic patients hospitalized with alcoholic hepatitis.

IF 2.7 4区 医学 Q2 Medicine
Canadian Journal of Gastroenterology Pub Date : 2013-11-01 Epub Date: 2013-09-13 DOI:10.1155/2013/930827
Paul J Thuluvath, Eric Ahn, Geoffrey C Nguyen
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引用次数: 3

Abstract

Objective: A nationwide analysis of alcoholic hepatitis (AH) admissions was conducted to determine the impact of hepatitis C virus (HCV) infection on short-term survival and hospital resource utilization.

Methods: Using the Nationwide Inpatient Sample, noncirrhotic patients admitted with AH throughout the United States between 1998 and 2006 were identified with diagnostic codes from the International Classification of Diseases, Ninth Revision. The in-hospital mortality rate (primary end point) of AH patients with and without co-existent HCV infection was determined. Hospital resource utilization was assessed as a secondary end point through linear regression analysis.

Results: From 1998 to 2006, there were 112,351 admissions for AH. In-hospital mortality was higher among patients with coexistent HCV infection (41.1% versus 3.2%; P=0.07). The adjusted odds of in-hospital mortality in the presence of HCV was 1.48 (95% CI 1.10 to 1.98). Noncirrhotic patients with AH and HCV also had longer length of stay (5.8 days versus 5.3 days; P<0.007) as well as greater hospital charges (US$25,990 versus US$21,030; P=0.0002).

Conclusions: Among noncirrhotic patients admitted with AH, HCV infection was associated with higher in-hospital mortality and resource utilization.

丙型肝炎作为非肝硬化酒精性肝炎住院患者的预后指标
目的:对全国酒精性肝炎(AH)住院患者进行分析,以确定丙型肝炎病毒(HCV)感染对短期生存和医院资源利用的影响。方法:使用全国住院患者样本,1998年至2006年期间美国住院的非肝硬化AH患者使用国际疾病分类第九版的诊断代码进行鉴定。确定合并和不合并HCV感染的AH患者的住院死亡率(主要终点)。通过线性回归分析评估医院资源利用作为次要终点。结果:1998年至2006年,共有112351例AH入院。合并HCV感染患者的住院死亡率更高(41.1% vs 3.2%;P = 0.07)。HCV存在的住院死亡率调整后的几率为1.48 (95% CI 1.10 - 1.98)。合并AH和HCV的非肝硬化患者的住院时间也更长(5.8天对5.3天;结论:在入院的非肝硬化AH患者中,HCV感染与较高的住院死亡率和资源利用率相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Canadian Journal of Gastroenterology
Canadian Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
4.00
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: Canadian Journal of Gastroenterology and Hepatology is a peer-reviewed, open access journal that publishes original research articles, review articles, and clinical studies in all areas of gastroenterology and liver disease - medicine and surgery. The Canadian Journal of Gastroenterology and Hepatology is sponsored by the Canadian Association of Gastroenterology and the Canadian Association for the Study of the Liver.
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