Jet fuel kerosene is not immunosuppressive in mice or rats following inhalation for 28 days.

Kimber L White, Michael P DeLorme, Patrick W Beatty, Matthew J Smith, Vanessa L Peachee
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引用次数: 9

Abstract

Previous reports indicated that inhalation of JP-8 aviation turbine fuel is immunosuppressive. However, in some of those studies, the exposure concentrations were underestimated, and percent of test article as vapor or aerosol was not determined. Furthermore, it is unknown whether the observed effects are attributable to the base hydrocarbon fuel (jet fuel kerosene) or to the various fuel additives in jet fuels. The present studies were conducted, in compliance with Good Laboratory Practice (GLP) regulations, to evaluate the effects of jet fuel kerosene on the immune system, in conjunction with an accurate, quantitative characterization of the aerosol and vapor exposure concentrations. Two female rodent species (B6C3F1 mice and Crl:CD rats) were exposed by nose-only inhalation to jet fuel kerosene at targeted concentrations of 0, 500, 1000, or 2000 mg/m(3) for 6 h daily for 28 d. Humoral, cell-mediated, and innate immune functions were subsequently evaluated. No marked effects were observed in either species on body weights, spleen or thymus weights, the T-dependent antibody-forming cell response (plaque assay), or the delayed-type hypersensitivity (DTH) response. With a few exceptions, spleen cell numbers and phenotypes were also unaffected. Natural killer (NK) cell activity in mice was unaffected, while the NK assessment in rats was not usable due to an unusually low response in all groups. These studies demonstrate that inhalation of jet fuel kerosene for 28 d at levels up to 2000 mg/m(3) did not adversely affect the functional immune responses of female mice and rats.

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喷射煤油在小鼠或大鼠体内吸入28天后没有免疫抑制作用。
先前的报告表明,吸入JP-8航空涡轮燃料具有免疫抑制作用。然而,在其中一些研究中,暴露浓度被低估了,并且测试物品作为蒸汽或气溶胶的百分比没有确定。此外,尚不清楚所观察到的影响是由于基础碳氢化合物燃料(喷气燃料煤油)还是喷气燃料中的各种燃料添加剂造成的。本研究是按照良好实验室规范(GLP)规定进行的,目的是评估航空煤油对免疫系统的影响,并结合气溶胶和蒸气暴露浓度的准确定量表征。两种雌性啮齿动物(B6C3F1小鼠和Crl:CD大鼠)通过仅鼻子吸入目标浓度为0、500、1000或2000 mg/m(3)的航空煤油,每天6小时,持续28天。随后评估体液、细胞介导和先天免疫功能。在体重、脾脏或胸腺重量、t依赖性抗体形成细胞反应(斑块测定)或延迟型超敏反应(DTH)反应方面,两种动物均未观察到明显影响。除少数例外,脾脏细胞数量和表型也未受影响。小鼠的自然杀伤(NK)细胞活性未受影响,而大鼠的NK评估由于所有组的异常低反应而不可用。这些研究表明,吸入高达2000 mg/m(3)的航空煤油28天不会对雌性小鼠和大鼠的功能性免疫反应产生不利影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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