The effect of race and chronic obstructive pulmonary disease on long-term survival after coronary artery bypass grafting.

Jimmy T Efird, Wesley T O'Neal, Curtis A Anderson, Jason B O'Neal, Linda C Kindell, T Bruce Ferguson, W Randolph Chitwood, Alan P Kypson
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引用次数: 22

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined. Methods: A retrospective cohort study was conducted of CABG patients between 2002 and 2011. Long-term survival was compared in patients with and without COPD and stratified by race. Hazard ratios (HR) and 95% confidence intervals (CI) were computed using a Cox regression model. Results: A total of 984 (20%) patients had COPD (black n = 182; white n = 802) at the time of CABG (N = 4,801). The median follow-up for study participants was 4.4 years. COPD was observed to be a statistically significant predictor of decreased survival independent of race following CABG (no COPD: HR = 1.0; white COPD: adjusted HR = 1.9, 95% CI = 1.7–2.3; black COPD: adjusted HR = 1.6, 95% CI = 1.1–2.2). Conclusion: Contrary to the expected increased risk of mortality among black COPD patients in the general population, a similar survival disadvantage was not observed in our CABG population.

Abstract Image

种族和慢性阻塞性肺疾病对冠状动脉旁路移植术后长期生存的影响。
背景:慢性阻塞性肺疾病(COPD)是冠状动脉旁路移植术(CABG)后长期生存率降低的已知预测因子。种族间的生存差异尚未被研究过。方法:对2002 ~ 2011年CABG患者进行回顾性队列研究。比较COPD患者和非COPD患者的长期生存率,并按种族分层。采用Cox回归模型计算风险比(HR)和95%置信区间(CI)。结果:共有984例(20%)患者患有COPD(黑色n = 182;白色n = 802), CABG时(n = 4801)。研究参与者的中位随访时间为4.4年。观察到COPD是CABG后独立于种族的生存率下降的统计学显著预测因子(无COPD: HR = 1.0;白色COPD:调整后HR = 1.9, 95% CI = 1.7-2.3;黑色COPD:调整后HR = 1.6, 95% CI = 1.1-2.2)。结论:与一般人群中黑人COPD患者死亡风险增加的预期相反,在我们的CABG人群中没有观察到类似的生存劣势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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