Smoking counteracts the favorable effect of exercise training on endothelial function in patients with type 2 diabetes.

Japanese clinical medicine Pub Date : 2013-04-09 eCollection Date: 2013-01-01 DOI:10.4137/JCM.S11152

Shinji Sato, Noriko Nakayama, Shingo Otsuki, Shiro Tanaka, Hajime Nakamura, Hiroyuki Koshiyama, Ryuji Nohara

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引用次数: 2

Abstract

Background: Exercise training can improve endothelial function in patients with diabetes. We hypothesized that the favorable effect of exercise training on endothelial function in patients with diabetes is counteracted by cigarette smoking.

Purpose: To assess whether there is a difference in the effect of exercise on endothelial function in smokers and non-smokers with type 2 diabetes.

Methods: We performed a 3-month controlled trial in 27 never-smoking and 17 smoking individuals with type 2 diabetes who participated in a home-based walking program. The percentage decrease in post-exercise ankle-brachial pressure index (ABI), which is an index of endothelial function, was assessed at baseline and after 3 months.

Results: Compared to the smoking group, the never-smoking group showed a more significant improvement in post exercise ABI during the 3 months of home-based training (interaction, P < 0.01).

Conclusions: These results indicate that smoking may counteract the favorable effects of exercise training on endothelial function. Endothelial function plays an important role in the prevention of cardiovascular disease among patients with diabetes. Therefore, a Certified Diabetes Educator should strongly advise diabetic patients not to smoke.

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吸烟抵消了运动训练对2型糖尿病患者内皮功能的有利影响。

背景:运动训练可以改善糖尿病患者的内皮功能。我们假设运动训练对糖尿病患者内皮功能的有利作用被吸烟抵消了。目的:评估吸烟和不吸烟的2型糖尿病患者运动对内皮功能的影响是否存在差异。方法:我们对27名从不吸烟的2型糖尿病患者和17名吸烟的2型糖尿病患者进行了为期3个月的对照试验，这些患者参加了以家庭为基础的步行计划。在基线和3个月后评估运动后踝肱压力指数(ABI)的百分比下降，ABI是内皮功能的指标。结果:与吸烟组相比，不吸烟组在3个月的家庭训练中运动后ABI改善更显著(交互作用，P < 0.01)。结论:这些结果表明吸烟可能抵消运动训练对内皮功能的有利影响。内皮功能在糖尿病患者心血管疾病的预防中起着重要作用。因此，注册糖尿病教育者应该强烈建议糖尿病患者不要吸烟。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Japanese clinical medicine

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