Intracellular and Extracellular miRNAs in Regulation of Angiogenesis Signaling.

Nnenna A Finn, Charles D Searles
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Abstract

Angiogenesis, the process by which new blood vessels are formed, is a critical phenomenon that is activated during various stages of mammalian development. MicroRNAs (miRNAs), a class of short, single stranded, non-coding RNAs, are recognized as important regulators of angiogenesis, and the role of intracellular miRNAs in modulating angiogenesis signaling has been identified. The recent discovery of extracellular and circulating miRNAs has sparked new questions regarding their potential in modulating angiogenesis signaling not only within cells but also between cells. In this review, we discuss the characteristics of intracellular and extracellular miRNAs and decipher the potential functional roles for these molecules in regard to the angiogenic process. We summarize what is currently known about circulating miRNAs in distinct clinical populations and discuss evidence that implicates extracellular miRNAs as novel mediators of angiogenesis-associated intercellular signaling. Lastly, we offer a new perspective on the functional role of vesicle-encapsulated circulating miRNA in modulating angiogenesis signaling pathways.

调节血管生成信号的细胞内和细胞外 miRNA。
血管生成是新血管形成的过程,是哺乳动物发育不同阶段激活的关键现象。微小RNA(miRNA)是一类短的单链非编码RNA,被认为是血管生成的重要调节因子,细胞内miRNA在调节血管生成信号中的作用已被确认。最近发现的细胞外和循环 miRNA 引发了新的问题,即它们不仅在细胞内,而且在细胞间调节血管生成信号的潜力。在这篇综述中,我们将讨论细胞内和细胞外 miRNA 的特点,并解读这些分子在血管生成过程中的潜在功能作用。我们总结了目前已知的不同临床人群中的循环 miRNA,并讨论了细胞外 miRNA 作为血管生成相关细胞间信号转导的新型介质的证据。最后,我们从一个新的角度探讨了囊泡包裹的循环 miRNA 在调节血管生成信号通路中的功能作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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