Central corneal melting associated with reformulated generic diclofenac in a patient with inferior fornix foreshortening.

Ophthalmology and eye diseases Pub Date : 2011-07-25 Print Date: 2011-01-01 DOI:10.4137/OED.S7300

Cameron Campbell Johnson

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引用次数: 4

Abstract

Purpose: To report a case of corneal melting in a patient with fornix foreshortening being treated with reformulated generic diclofenac.

Methods: Case report.

Results: An asymptomatic 76-year old man presented with central corneal melting while being treated with reformulated generic diclofenac. This formulation did not contain the vitamin E derivative, tocophersolan, which has been felt to contribute to corneal melting associated with generic diclofenac in the past. Other factors for corneal melting included multiple medication use and altered forniceal architecture, but did not include previous corneal or cataract surgery. Following discontinuation of the topical medications and temporary tarsorrhapy, the defect reepithelialized.

Conclusion: In patients with a compromised ocular surface, reformulated generic diclofenac has the potential to cause corneal melting without prior cataract or refractive surgery. Use should not be indiscriminate or without close supervision.

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下穹窿前缩患者中央性角膜融化与重新配制的通用双氯芬酸相关。

目的:报告一个用双氯芬酸治疗穹窿前缩症患者角膜融化的病例。方法:病例报告。结果:一名无症状的76岁男性在使用双氯芬酸治疗时出现中央角膜融化。该配方不含维生素E衍生物，生育酚，这被认为有助于角膜融化与通用双氯芬酸在过去。其他导致角膜融化的因素包括多种药物的使用和穹窿结构的改变，但不包括以前的角膜或白内障手术。局部药物停用和暂时性损伤后，缺损重新上皮化。结论:对于眼表受损的患者，在没有白内障或屈光手术的情况下，重新配制的通用双氯芬酸有可能导致角膜融化。不得随意使用或没有严密监督。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ophthalmology and eye diseases

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审稿时长

8 weeks