Principal components analysis of atopy-related traits in a random sample of children.

ISRN allergy Pub Date : 2011-06-15 Print Date: 2011-01-01 DOI:10.5402/2011/170989

Simon Francis Thomsen, Vibeke Backer

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Abstract

Aim. To study the relationship between atopy-related traits in a random sample of children. Methods. A total of 1007 randomly selected children, 7-17 years of age, from Copenhagen, Denmark were studied. The children were interviewed about symptoms of atopic diseases, and skin test reactivity, serum total IgE, lung function, and airway responsiveness were measured. Principal components analysis was performed in order to examine the relationship between the different traits. Results. Most of the studied traits were significantly correlated. A three-component solution explained about 55% of the variation in the observed traits. The first component loaded most strongly on hay fever, serum total IgE, skin test reactivity and sensitisation to grass, cat and house dust mite allergen; the second factor was most associated with asthma, airway obstruction, and airway hyperresponsiveness, whereas the third factor corresponded most strongly to atopic dermatitis. There was some indication of cross-relations between the three components with respect to serum total IgE. Conclusion. Asthma, hay fever, and atopic dermatitis are characterised by different sets of biomarkers suggestive of a high degree of heterogeneity within the atopic syndrome.

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随机儿童异位相关性状的主成分分析。

的目标。目的:研究随机抽样儿童异位相关性状之间的关系。方法。研究人员从丹麦哥本哈根随机抽取了1007名7-17岁的儿童。对儿童进行了特应性疾病症状的访谈，并测量了皮肤试验反应性、血清总IgE、肺功能和气道反应性。为了检验不同性状之间的关系，进行了主成分分析。结果。所研究性状大部分呈显著相关。一个由三部分组成的解决方案解释了观察到的性状中约55%的变化。第一种成分对花粉热、血清总IgE、皮肤试验反应性和对草、猫和屋尘螨过敏原的致敏性影响最大;第二个因素与哮喘、气道阻塞和气道高反应性最相关，而第三个因素与特应性皮炎最相关。这三种成分与血清总IgE之间有一定的交叉关系。结论。哮喘、花粉热和特应性皮炎以不同的生物标志物为特征，表明特应性综合征具有高度的异质性。

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ISRN allergy

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