Exposure to the endocrine disruptor nonylphenol alters structure and function of thyroid gland in rats

Regulatory Peptides Pub Date : 2013-08-10 DOI:10.1016/j.regpep.2013.06.004

Yue Xi , Dehua Li , Wei San

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引用次数: 17

Abstract

Objective

Nonylphenol (NP) is an estrogenic-like compound which can induce vitellogenin synthesis in males and immature teleostean species. Known as an endocrine disruptor, it has been reported to affect endocrine glands; however, little is known about its effects on thyroid function. The present study aimed to evaluate whether exposure to NP alters the structure and function of the thyroid gland of rats and/or the underlying mechanisms.

Methods

Rats were gavaged with NP (40, 80 and 200 mg/kg/d) for 15 days. Serum levels of thyroid-stimulating hormone were determined by radioimmunoassay. Ultramicroscopic structure of follicular cells was examined by a transmission electron microscope. Histopathology was conducted with hematoxylin-eosin (HE) staining.

Results

We found that NP exposure induced a decrease in serum levels of free tetraiodothyronine (FT) 3 and FT4 while it induced an increase in serum levels of thyroid-stimulating hormone (TSH) in a dose-dependent manner. There was a negative correlation between different doses of NP with serum levels of FT3 and FT4 (FT4 r = − 0.932; FT3 r = − 0.926) and a positive correlation with serum levels of TSH (r = 0.967). Histological and morphometric study in the NP-exposed group revealed dilation of endoplasmic reticulum into cystic in thyroid follicular cells. Mitochondrion was damaged in the 80 and 200 mg/kg/d groups.

Conclusions

Exposure to NP may lead to thyroid dysfunction. It may be a potential contributor to thyroid disruption.

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暴露于内分泌干扰物壬基酚会改变大鼠甲状腺的结构和功能

目的壬基酚(NP)是一种雌激素样化合物，可诱导雄性和未成熟硬骨鱼合成卵黄蛋白原。它被称为内分泌干扰物，据报道会影响内分泌腺;然而，人们对其对甲状腺功能的影响知之甚少。本研究旨在评估暴露于NP是否会改变大鼠甲状腺的结构和功能和/或潜在的机制。方法大鼠分别灌胃NP(40、80、200 mg/kg/d) 15 d。用放射免疫法测定血清促甲状腺激素水平。透射电镜观察卵泡细胞超微结构。采用苏木精-伊红(HE)染色进行组织病理学检查。结果NP暴露诱导血清游离四碘甲状腺原氨酸(FT) 3和FT4水平降低，同时诱导血清促甲状腺激素(TSH)水平呈剂量依赖性升高。不同剂量NP与血清FT3、FT4水平呈负相关(FT4 r = - 0.932;FT3 r =−0.926)，与血清TSH水平呈正相关(r = 0.967)。np暴露组的组织学和形态学研究显示甲状腺滤泡细胞内质网扩张成囊状。80和200 mg/kg/d组线粒体受到损伤。结论NP暴露可导致甲状腺功能障碍。它可能是甲状腺功能紊乱的潜在因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regulatory Peptides 医学-内分泌学与代谢

自引率

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审稿时长

2 months

期刊介绍： Regulatory Peptides provides a medium for the rapid publication of interdisciplinary studies on the physiology and pathology of peptides of the gut, endocrine and nervous systems which regulate cell or tissue function. Articles emphasizing these objectives may be based on either fundamental or clinical observations obtained through the disciplines of morphology, cytochemistry, biochemistry, physiology, pathology, pharmacology or psychology.

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