{"title":"Free fatty acid oxidation in insulin resistance and obesity.","authors":"E Dale Abel","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>The growing worldwide epidemic of obesity and diabetes portends a significant increase in cardiovascular disease. Obesity is associated with insulin resistance, and there is growing evidence that these conditions independently increase the risk of heart failure. Changes in myocardial substrate utilization develop in obesity and insulin resistance, and are characterized by increased fatty acid oxidation and utilization, and decreased glucose utilization. This paper will review the evidence for altered myocardial fatty acid utilization in obesity and insulin resistance, review mechanisms that are responsible, and discuss the relative contributions of systemic and myocardial insulin resistance in the regulation of fatty acid utilization in the heart.</p>","PeriodicalId":35477,"journal":{"name":"Heart and Metabolism","volume":"48 ","pages":"5-10"},"PeriodicalIF":0.0000,"publicationDate":"2010-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643515/pdf/nihms-435217.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Heart and Metabolism","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
The growing worldwide epidemic of obesity and diabetes portends a significant increase in cardiovascular disease. Obesity is associated with insulin resistance, and there is growing evidence that these conditions independently increase the risk of heart failure. Changes in myocardial substrate utilization develop in obesity and insulin resistance, and are characterized by increased fatty acid oxidation and utilization, and decreased glucose utilization. This paper will review the evidence for altered myocardial fatty acid utilization in obesity and insulin resistance, review mechanisms that are responsible, and discuss the relative contributions of systemic and myocardial insulin resistance in the regulation of fatty acid utilization in the heart.
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