Quantitative structure-activity relationship analysis of thiazolidineones: potent antidiabetic compounds.

Vijay Kumar Vishvakarma, Prashant Singh, Monica Dubey, Kamlesh Kumari, Ramesh Chandra, Narender D Pandey
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引用次数: 3

Abstract

Background: Type 2 diabetes is the most common form of diabetes, accounting for over 90% of cases. Current treatment approaches for type 2 diabetes include diet, exercise, and a variety of pharmacologic agents, including insulin, biguanides, sulfonylureas, and thiazolidinediones.

Methods: In the present scenario, researchers focused themselves on thiazolidine ring-based compounds to cure type 2 diabetes mellitus. Among the peroxisome proliferator activated receptor (PPAR) family, PPAR-γ is the most effective in curing glucose homeostasis.

Results and conclusions: Thiazolidine ring-based compounds act as PPAR-γ agonists, and herein, we have successfully developed nine derivatives of thiazolidine ring-based compounds that are found to be biologically potent using two-dimensional quantitative structure-activity relationship model.

有效抗糖尿病化合物噻唑烷酮的定量构效关系分析。
背景:2型糖尿病是最常见的糖尿病形式,占90%以上的病例。目前2型糖尿病的治疗方法包括饮食、运动和多种药物,包括胰岛素、双胍类、磺脲类和噻唑烷二酮类。方法:目前,研究人员将重点放在噻唑烷环类化合物治疗2型糖尿病上。在过氧化物酶体增殖物激活受体(PPAR)家族中,PPAR-γ在葡萄糖稳态中最有效。结果与结论:基于噻唑烷环的化合物作为PPAR-γ激动剂,在此基础上,我们成功地开发了9个基于噻唑烷环的化合物衍生物,并通过二维定量构效关系模型发现它们具有生物活性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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