Can Vitamin D Supplementation Improve the Severity of Congestive Heart Failure?

Congestive heart failure (Greenwich, Conn.) Pub Date : 2013-03-21 DOI:10.1111/chf.12026

Ahmad Amin MD, Shima Minaee MD, Mitra Chitsazan MD, Nassim Naderi MD, Sepideh Taghavi MD, Maryam Ardeshiri MD

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引用次数: 37

Abstract

The aim of the present study was to investigate whether vitamin D supplementation could improve biochemical findings and functional capacity of patients with heart failure (HF). One hundred patients with New York Heart Association (NYHA) class I through III HF were included in this prospective study and their 25-hydroxyvitamin D levels were evaluated. Only 6% of the participants had a sufficient serum concentration of 25(OH) D >30 nmol/L. Patients with insufficient or deficient serum levels of 25(OH) D (<30 ng/mL and <20 ng/mL, respectively) received oral vitamin D₃ (cholecalciferol) for a total period of 4 months. Vitamin D supplementation increased mean serum concentration of 25(OH) D from 12.63±7.60 nmol/L to 54.49±18.01 nmol/L (P<.001). After vitamin D supplementation, the serum level of pro-brain natriuretic peptide markedly decreased (P<.001). Cholecalciferol significantly decreased high-sensitivity C-reactive protein level (P<.001). Restoration of serum 25(OH) D level was also associated with substantial improvement in NYHA class (P<.001) and 6-minute walk distance (P<.001).

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补充维生素D能改善充血性心力衰竭的严重程度吗?

本研究的目的是研究补充维生素D是否可以改善心力衰竭(HF)患者的生化结果和功能能力。该前瞻性研究纳入了100例纽约心脏协会(NYHA) I至III级心衰患者，并评估了他们的25-羟基维生素D水平。只有6%的参与者有足够的血清浓度25(OH) D >30 nmol/L。血清25(OH) D水平不足或缺乏(分别为30 ng/mL和20 ng/mL)的患者接受口服维生素D3(胆钙化醇)，疗程共4个月。补充维生素D使25(OH) D的平均血清浓度从12.63±7.60 nmol/L增加到54.49±18.01 nmol/L (P<.001)。补充维生素D后，血清前脑利钠肽水平显著降低(p < 0.01)。胆钙化醇显著降低高敏c反应蛋白水平(p < 0.01)。血清25(OH) D水平的恢复也与NYHA等级(P<.001)和6分钟步行距离(P<.001)的显著改善有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Congestive heart failure (Greenwich, Conn.)

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