[Factors linked to rapid progression to AIDS in Cuban subjects].

Q4 Medicine
Revista Cubana de Medicina Tropical Pub Date : 2010-05-01
Yeissel Abrahantes Rodríguez, Jorge Pérez Avila, Vivian Kouri Cardellá, Carlos Fonseca Gómez, Alberto Baly Gil, Thelma Tápanes Fernandez
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引用次数: 0

Abstract

Introduction: in the last few years, the number of HIV Cuban patients expressing rapid clinical and immunologic deterioration has increased.

Objective: to find out the possible factors associated to rapid progression to AIDS.

Methods: a case-control study was carried out with the objective of determining possible factors associated with rapid progression to AIDS. Twenty six patients with rapid progression to AIDS, who were seen at "Pedro Kouri" Institute of Tropical Medicine from September 2007 to August 2008 together with two 20- patient control groups (A and B) were involved in the study. Social, demographic, clinical and laboratory variables were analyzed. By means of multivariate logistic analysis, the association between the exposure variables and the rapid progression to AIDS was determined.

Results: the variables associated with rapid progression to AIDS using the punctual estimate of the Odds ratio (OR > or = 2) were: female (OR: 17.0), non-use of condom (OR: 3.24), percentage of TCD4+ lymphocytes at the moment of HIV diagnosis < or = 25% (OR: 8.0) and the absolute count < or = 400 cel/mm3 (OR: 3.27), oral candidiasis (OR: 66.20), and an HIV viral load > 10 000 UI/mL at the moment of the diagnosis (OR: 4.62). The age older than 30 years at HIV diagnosis, the toxic habits, the symptomatic syndrome of acute retrovirosis and the rest of the co-infections were not associated with rapid progression to AIDS.

Conclusions: besides those well-known viral and immunologic factors, there are other clinical and epidemiological factors associated with rapid progression to AIDS such as being female, non-use of condon, oral candiasis, T cell CD4+ count and viral load. All of them must be taken into account at the moment of initial patient assessment.

[与古巴受试者艾滋病迅速发展有关的因素]。
简介:近年来,古巴艾滋病患者表现出临床和免疫迅速恶化的人数有所增加。目的:探讨艾滋病快速发展的可能因素。方法:进行病例对照研究,目的是确定与艾滋病快速进展相关的可能因素。2007年9月至2008年8月在Pedro Kouri热带医学研究所就诊的26例艾滋病快速进展患者与两个20例患者对照组(A和B)一起参与了这项研究。分析社会、人口、临床和实验室变量。通过多变量logistic分析,确定暴露变量与艾滋病快速进展之间的关系。结果:使用比值比准时估计(OR > OR = 2)与艾滋病快速进展相关的变量为:女性(OR: 17.0),未使用安全套(OR: 3.24), HIV诊断时TCD4+淋巴细胞百分比< OR = 25% (OR: 8.0),绝对计数< OR = 400细胞/mm3 (OR: 3.27),口腔念珠菌病(OR: 66.20),以及诊断时HIV病毒载量> 10,000 UI/mL (OR: 4.62)。诊断时年龄大于30岁、中毒习惯、急性逆转录病毒病症状综合征和其他合并感染与快速发展为艾滋病无关。结论:除已知的病毒和免疫因素外,女性、未使用避孕套、口腔念珠菌感染、T细胞CD4+计数和病毒载量等临床和流行病学因素与艾滋病快速进展有关。在对患者进行初步评估时,必须考虑到所有这些因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Revista Cubana de Medicina Tropical
Revista Cubana de Medicina Tropical Medicine-Infectious Diseases
CiteScore
0.30
自引率
0.00%
发文量
0
期刊介绍: La Revista Cubana de Medicina Tropical tiene la misión de publicar artículos científicos especializados en medicina tropical, microbiología, parasitología, epidemiología y otras especialidades afines. Se distribuye directamente por el editor a los suscriptores en formato impreso (ISSN 0375-0760). Está dirigida a profesionales y técnicos en el campo de la medicina tropical, microbiología, parasitología y epidemiología. Recibe contribuciones en idioma español, inglés y portugués sin distinción en el país de procedencia.
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