Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers.

Oncology (Williston Park, N.Y.) Pub Date : 2012-11-01
Nicole Shonka, Alba Brandes, John F De Groot
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引用次数: 0

Abstract

Although they represent the most common malignant brain tumor in the pediatric population, medulloblastomas are rare in adults, with an incidence of 0.5 per million. With only one exception, all of the prospective clinical trials in this disease have been done in the pediatric population, and therefore therapy for adult medulloblastoma has been either extrapolated from the pediatric literature or based on retrospective reviews. A growing body of literature underscores the genetic similarities between adult and pediatric disease, which may allow tailored therapy directed towards specific molecular pathways and may have an impact on clinical outcomes. Here we present the history, staging system, and treatment of medulloblastoma, reviewing the prognostic value and clinical application of molecular subtyping while highlighting the differences between adult and pediatric disease.

成人髓母细胞瘤,从小脑海绵母细胞瘤到现在:治疗和分子标记整合的综述。
虽然髓母细胞瘤是儿童中最常见的恶性脑肿瘤,但在成人中却很少见,发病率为百万分之0.5。除了一个例外,该疾病的所有前瞻性临床试验都是在儿科人群中进行的,因此成人髓母细胞瘤的治疗要么是从儿科文献中推断出来的,要么是基于回顾性综述。越来越多的文献强调了成人和儿科疾病之间的遗传相似性,这可能允许针对特定分子途径的量身定制治疗,并可能对临床结果产生影响。在这里,我们介绍髓母细胞瘤的历史、分期系统和治疗,回顾分子分型的预后价值和临床应用,同时强调成人和儿童疾病的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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