Type 2 innate lymphoid cells: friends or foes-role in airway allergic inflammation and asthma.

Journal of allergy Pub Date : 2012-01-01 Epub Date: 2012-11-11 DOI:10.1155/2012/130937
Abbas Pishdadian, Abdol-Reza Varasteh, Mojtaba Sankian
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引用次数: 9

Abstract

Innate-like lymphocytes (ILLs) and innate lymphoid cells (ILCs) are two newly characterized families of lymphocytes with limited and no rearranged antigen receptors, respectively. These soldiers provide a first line of defense against foreign insults by triggering a prompt innate immune response and bridging the gap of innate and adaptive immunity. Type 2 innate lymphoid cells (ILCs2) are newly identified members of the ILC family that play a key role in type 2 immune responses by prompt production of type 2 cytokines (especially IL-5 and IL-13) in response to antigen-induced IL-25/33 and by recruiting type 2 "immune franchise." Regarding the two different roles of type 2 cytokines, helminth expulsion and type 2-related diseases, here we review the latest advances in ILC2 biology and examine the pivotal role of resident ILCs2 in allergen-specific airway inflammation and asthma.

2型先天淋巴样细胞:朋友还是敌人——在气道变应性炎症和哮喘中的作用。
先天淋巴细胞(innate -like lymphoid cells, ILLs)和先天淋巴细胞(innate lymphoid cells, ILCs)是两种新发现的具有有限和无重排抗原受体的淋巴细胞家族。这些士兵通过触发迅速的先天免疫反应和弥合先天免疫和适应性免疫的差距,为抵御外来侮辱提供了第一道防线。2型先天淋巴样细胞(ILCs2)是ILC家族中新发现的成员,在2型免疫应答中发挥关键作用,在应答抗原诱导的IL-25/33时,通过迅速产生2型细胞因子(特别是IL-5和IL-13),并通过招募2型“免疫特许”。针对2型细胞因子的两种不同作用,寄生虫驱逐和2型相关疾病,本文综述了ILC2生物学的最新进展,并探讨了常驻ILCs2在过敏原特异性气道炎症和哮喘中的关键作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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