Role of killer immunoglobulin-like receptor and ligand matching in donor selection.

Bone Marrow Research Pub Date : 2012-01-01 Epub Date: 2012-11-10 DOI:10.1155/2012/271695
Meral Beksaç, Klara Dalva
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引用次数: 13

Abstract

Despite all efforts to improve HLA typing and immunosuppression, it is still impossible to prevent severe graft versus host disease (GVHD) which can be fatal. GVHD is not always associated with graft versus malignancy and can prevent stem cell transplantation from reaching its goals. Overall T-cell alloreactivity is not the sole mechanism modulating the immune defense. Innate immune system has its own antigens, ligands, and mediators. The bridge between HLA and natural killer (NK) cell-mediated reactions is becoming better understood in the context of stem cell transplantation. Killer immunoglobulin-like receptors (KIRs) constitute a wide range of alleles/antigens segregated independently from the HLA alleles and classified into two major haplotypes which imprints the person's ability to suppress or to amplify T-cell alloreactivity. This paper will summarize the impact of both activating and inhibitory KIRs and their ligands on stem cell transplantation outcome. The ultimate goal is to develop algorithms based on KIR profiles to select donors with maximum antileukemic and minimum antihost effects.

杀伤免疫球蛋白样受体和配体在供体选择中的作用。
尽管所有努力改善HLA分型和免疫抑制,仍然不可能预防严重的移植物抗宿主病(GVHD),这可能是致命的。GVHD并不总是与移植物抗恶性肿瘤相关,并且可以阻止干细胞移植达到其目标。总的t细胞同种异体反应性并不是调节免疫防御的唯一机制。先天免疫系统有自己的抗原、配体和介质。在干细胞移植的背景下,HLA和自然杀伤(NK)细胞介导的反应之间的桥梁正在得到更好的理解。杀伤免疫球蛋白样受体(KIRs)由一系列独立于HLA等位基因的等位基因/抗原组成,分为两种主要的单倍型,这两种单倍型决定了人抑制或增强t细胞同种异体反应的能力。本文将综述激活和抑制KIRs及其配体对干细胞移植结果的影响。最终目标是开发基于KIR谱的算法,以选择具有最大抗白血病作用和最小抗宿主作用的供体。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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