Crystallization of the DdrB-DNA complex from Deinococcus radiodurans.

IF 0.9 4区生物学

Acta Crystallographica Section F-structural Biology and Crystallization Communications Pub Date : 2012-12-01 Epub Date: 2012-11-14 DOI:10.1107/S1744309112044041

Seiji Sugiman-Marangos, Murray Junop

引用次数: 0

Abstract

The remarkable ability of members of the Deinococcus family to recover from extreme DNA damage is in part owing to their robust DNA-repair mechanisms. Of particular interest is their ability to repair hundreds of double-strand DNA breakages through a rapid and efficient mechanism involving novel proteins that are uniquely found in Deinococcus spp. One such protein, DdrB, which is thought to play a role early in DSB repair, has been crystallized in complex with ssDNA and data have been collected to 2.3 Å resolution.

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放射球菌 DdrB-DNA 复合物的结晶。

脱氧核糖核酸（DNA）家族成员之所以能从极端的 DNA 损伤中恢复过来，部分原因是它们具有强大的 DNA 修复机制。其中一种蛋白质 DdrB 被认为在 DSB 修复的早期阶段发挥作用，它与 ssDNA 的复合体已经结晶，数据的分辨率达到 2.3 Å。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Crystallographica Section F-structural Biology and Crystallization Communications 生物-晶体学

自引率

0.00%

发文量

审稿时长

2-4 weeks

期刊介绍： Acta Crystallographica Section F is a rapid structural biology communications journal. Articles on any aspect of structural biology, including structures determined using high-throughput methods or from iterative studies such as those used in the pharmaceutical industry, are welcomed by the journal. The journal offers the option of open access, and all communications benefit from unlimited free use of colour illustrations and no page charges. Authors are encouraged to submit multimedia content for publication with their articles. Acta Cryst. F has a dedicated online tool called publBio that is designed to make the preparation and submission of articles easier for authors.