Interactions of Mn2+ with a non-self-complementary Z-type DNA duplex.

IF 0.9 4区生物学

Acta Crystallographica Section F-structural Biology and Crystallization Communications Pub Date : 2012-12-01 Epub Date: 2012-11-14 DOI:10.1107/S1744309112041759

P K Mandal, S Venkadesh, N Gautham

引用次数: 7

Abstract

Crystal structures of the hexanucleotide d(CACGCG)·d(CGCGTG) were determined in two crystal lattices when different concentrations of the counterion Mn2+ were used in crystallization. The availability of Mn2+ during the crystallization process appears to play an important role in inducing different crystal packings that lead to crystals belonging to the two space groups P2(1) and P6(5). Analysis of the molecular interactions of Mn2+ with the Z-form duplexes shows direct coordination to the purine residues G and A.

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Mn2+与非自互补的z型DNA双工的相互作用。

用不同浓度的反离子Mn2+对六核苷酸d（CACGCG）·d（CGCGTG）在两个晶格中的晶体结构进行了测定。结晶过程中Mn2+的可用性似乎在诱导不同的晶体填充中起着重要作用，这些晶体填充导致属于两个空间群P2（1）和P6（5）的晶体。Mn2+与Z型双链体的分子相互作用的分析显示与嘌呤残基G和A直接配位。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta Crystallographica Section F-structural Biology and Crystallization Communications 生物-晶体学

自引率

0.00%

发文量

审稿时长

2-4 weeks

期刊介绍： Acta Crystallographica Section F is a rapid structural biology communications journal. Articles on any aspect of structural biology, including structures determined using high-throughput methods or from iterative studies such as those used in the pharmaceutical industry, are welcomed by the journal. The journal offers the option of open access, and all communications benefit from unlimited free use of colour illustrations and no page charges. Authors are encouraged to submit multimedia content for publication with their articles. Acta Cryst. F has a dedicated online tool called publBio that is designed to make the preparation and submission of articles easier for authors.