An Investigation of Siloxane Cross-linked Hydroxyapatite-Gelatin/Copolymer Composites for Potential Orthopedic Applications().

Journal of Materials Chemistry Pub Date : 2012-01-01 Epub Date: 2012-09-07 DOI:10.1039/C2JM32466K
Jason Christopher Dyke, Kelly Jane Knight, Huaxing Zhou, Chi-Kai Chiu, Ching-Chang Ko, Wei You
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引用次数: 20

Abstract

Causes of bone deficiency are numerous, but biomimetic alloplastic grafts provide an alternative to repair tissue naturally. Previously, a hydroxyapatite-gelatin modified siloxane (HAp-Gemosil) composite was prepared by cross-linking (N, N'-bis[(3-trimethoxysilyl)propyl]ethylene diamine (enTMOS) around the HAp-Gel nanocomposite particles, to mimic the natural composition and properties of bone. However, the tensile strength remained too low for many orthopedic applications. It was hypothesized that incorporating a polymer chain into the composite could help improve long range interaction. Furthermore, designing this polymer to interact with the enTMOS siloxane cross-linked matrix would provide improved adhesion between the polymer and the ceramic composite, and improve mechanical properties. To this end, copolymers of L-Lactide (LLA), and a novel alkyne derivatized trimethylene carbonate, propargyl carbonate (PC), were synthesized. Incorporation of PC during copolymerization affects properties of copolymers such as molecular weight, T(g), and % PC incorporation. More importantly, PC monomers bear a synthetic handle, allowing copolymers to undergo post-polymerization functionalization with graft monomers to specifically tailor the properties of the final composite. For our investigation, P(LLA-co-PC) copolymers were functionalized by an azido-silane (AS) via copper catalyzed azide-alkyne cycloaddition (CuAAC) through terminal alkyne on PC monomers. The new functionalized polymer, P(LLA-co-PC)(AS) was blended with HAp-Gemosil, with the azido-silane linking the copolymer to the silsesquioxane matrix within the final composite.These HAp-Gemosil/P(LLA-co-PC)(AS) composites were subjected to mechanical and biological testing, and the results were compared with those from the HAp-Gemosil composites. This study revealed that incorporating a cross-linkable polymer served to increase the flexural strength of the composite by 50%, while maintaining the biocompatibility of HAp-Gemosil ceramics.
硅氧烷交联羟基磷灰石-明胶/共聚物复合材料在骨科中的潜在应用研究()。
骨缺乏的原因有很多,但仿生同种异体移植物提供了一种自然修复组织的替代方法。先前,通过在HAp-Gel纳米复合颗粒周围交联(N, N'-双[(3-三甲氧基硅基)丙基]乙二胺(enTMOS),制备了羟基磷灰石-明胶改性硅氧烷(HAp-Gemosil)复合材料,以模拟骨的天然组成和性能。然而,拉伸强度仍然太低,许多矫形应用。据推测,在复合材料中加入聚合物链可以帮助改善远程相互作用。此外,设计这种聚合物与enTMOS硅氧烷交联基体相互作用将改善聚合物与陶瓷复合材料之间的附着力,并改善机械性能。为此,合成了l -丙交酯(LLA)和一种新型的炔衍生化碳酸三亚甲基丙炔酯(PC)的共聚物。共聚过程中PC的掺入会影响共聚物的性质,如分子量、T(g)和PC掺入率。更重要的是,PC单体具有合成手柄,允许共聚物与接枝单体进行聚合后功能化,以专门定制最终复合材料的性能。在我们的研究中,P(LLA-co-PC)共聚物通过铜催化叠氮化物-炔环加成(CuAAC)在PC单体上通过末端炔被叠氮硅烷(AS)功能化。新的功能化聚合物P(LLA-co-PC)(AS)与HAp-Gemosil共混,叠氮硅烷将共聚物与最终复合材料中的硅氧烷基体连接起来。对这些HAp-Gemosil/P(la -co- pc)(AS)复合材料进行了力学和生物学测试,并与HAp-Gemosil复合材料的结果进行了比较。该研究表明,加入交联聚合物可以将复合材料的抗弯强度提高50%,同时保持HAp-Gemosil陶瓷的生物相容性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Materials Chemistry
Journal of Materials Chemistry 工程技术-材料科学:综合
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1.5 months
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