Evaluation of the effect of statin use on the acenocoumarol and phenprocoumon maintenance dose.

Drug Metabolism and Drug Interactions Pub Date : 2012-01-01 DOI:10.1515/dmdi-2012-0024

Rianne M F van Schie, Talitha I Verhoef, Saskia B Boejharat, Tom Schalekamp, Judith A M Wessels, Saskia le Cessie, Frits R Rosendaal, Felix J M van der Meer, Anthonius de Boer, Anke-Hilse Maitland-van der Zee

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引用次数: 10

Abstract

Background: Statins and coumarins are prescribed in combination on a regular basis. Some case reports suggested that statins might affect the dose requirements of coumarins. The aim of the study was to investigate whether acenocoumarol and phenprocoumon maintenance doses are influenced by statin use.

Methods: The Pre-EU-PACT database was used, which contains information on 471 acenocoumarol and 624 phenprocoumon users. The influence of individual statins on the acenocoumarol and phenprocoumon maintenance dose was investigated by comparing unadjusted and adjusted mean differences of the maintenance dose between statin and non-statin users.

Results: Lower adjusted acenocoumarol dose requirements were observed for patients using atorvastatin, simvastatin, pravastatin, and rosuvastatin. These patients had a reduction in adjusted mean acenocoumarol maintenance dose of 0.11, 0.29, 0.38, and 0.69 mg/day, respectively, compared with a mean adjusted dose of 2.60 mg/day for the patients not using a statin. There was no significant effect of statin use on unadjusted and adjusted phenprocoumon maintenance dose (p=0.23 and p=0.35, respectively).

Conclusions: Mean acenocoumarol maintenance dosages were decreased when acenocoumarol is co-administered with the different statins. Statin use does not affect phenprocoumon maintenance doses significantly.

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评价他汀类药物使用对阿塞诺古玛尔和苯丙酚维持剂量的影响。

背景:他汀类药物和香豆素是常规联合用药。一些病例报告表明，他汀类药物可能会影响香豆素的剂量需求。该研究的目的是调查阿塞诺古豆素和苯丙酚维持剂量是否受他汀类药物使用的影响。方法:采用Pre-EU-PACT数据库，该数据库包含471名阿塞诺香豆素使用者和624名phenprocoumon使用者的信息。通过比较他汀类药物使用者与非他汀类药物使用者之间未调整和调整后维持剂量的平均差异，研究单个他汀类药物对阿塞诺古玛尔和phenprocoumon维持剂量的影响。结果:观察到阿托伐他汀、辛伐他汀、普伐他汀和瑞舒伐他汀患者调整后的阿塞诺香豆醇剂量需求较低。与未使用他汀类药物的患者的平均调整剂量2.60 mg/天相比，这些患者的调整平均阿塞诺香豆醇维持剂量分别减少了0.11、0.29、0.38和0.69 mg/天。他汀类药物的使用对未调整和调整phenprocoumon维持剂量无显著影响(p=0.23和p=0.35)。结论:与不同的他汀类药物合用时，阿塞诺香豆素的维持剂量降低。他汀类药物的使用对phenprocoumon维持剂量没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Drug Metabolism and Drug Interactions

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