{"title":"Unlocking the mechanisms of HCN channel gating with locked-open and locked-closed channels.","authors":"Matthew C Trudeau","doi":"10.1085/jgp.201210898","DOIUrl":null,"url":null,"abstract":"Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmembrane voltage and chemical ligands ([Hille, 2001][1]). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and","PeriodicalId":173753,"journal":{"name":"The Journal of General Physiology","volume":" ","pages":"457-61"},"PeriodicalIF":0.0000,"publicationDate":"2012-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1085/jgp.201210898","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of General Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1085/jgp.201210898","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2012/10/15 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 4
Abstract
Ion channels are highly specialized to respond to a wide range of environmental stimuli, including transmembrane voltage and chemical ligands ([Hille, 2001][1]). The response of channels to external cues causes a change in their ion conduction, which, in turn, modifies the behavior of excitable and