Shared predispositions of parkinsonism and cancer: a population-based pedigree-linked study.

Seth A Kareus, Karla P Figueroa, Lisa A Cannon-Albright, Stefan M Pulst
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引用次数: 75

Abstract

OBJECTIVE To use a statewide population-based genealogic database to evaluate the relationship between Parkinson disease (PD) and cancer subtypes. DESIGN Using a computerized genealogy for the Utah pioneers and their descendants linked to a statewide cancer registry and statewide death certificates, we estimated relative risks for cancer in individuals with PD listed on their death certificate, and in their first-degree, second-degree, and third-degree relatives. SETTING Utah Cancer Registry. PARTICIPANTS Approximately 2.3 million individuals in the Utah genealogic resource, including death certificates of 2998 individuals with PD listed as a cause of death from 1904 to 2008 and information on 100 817 individuals with a cancer diagnosis in the Utah Cancer Registry. RESULTS Melanoma and prostate cancer were the only cancers observed in significant excess among PD cases; colorectal, lung, pancreas, and stomach cancers were observed in deficit. A significantly increased risk for prostate cancer was observed in the PD population as well as among their relatives. A reciprocal significantly increased risk for PD was also found in the 22 147 prostate cancer cases and their relatives. A significantly elevated risk for melanoma was found in the Utah PD population as well as in their relatives. A reciprocal significantly increased relative risk for PD was found in 7841 Utah melanoma cases and their relatives. CONCLUSIONS Our study identified a novel association between PD and prostate cancer, which extended to first-degree, second-degree, and third-degree relatives. We also confirmed the reported risk association for melanoma in patients with PD; we extended the finding to include a significantly increased risk in relatives. These results strongly support a genetic link. This conclusion is further strengthened by observation of the reciprocal relationship, an increased risk for PD in relatives of individuals with melanoma or prostate cancer.

帕金森病和癌症的共同易感性:一项基于人群的谱系关联研究。
目的:利用一个以美国人口为基础的家谱数据库来评估帕金森病(PD)与癌症亚型之间的关系。设计:使用与全州癌症登记和全州死亡证明相关联的犹他州先驱者及其后代的计算机家谱,我们估计了死亡证明上列出的PD患者及其一级、二级和三级亲属患癌症的相对风险。设置犹他州癌症登记处。参与者在犹他州的家谱资源中大约有230万人,包括2998名PD患者的死亡证明,这些死亡证明被列为1904年至2008年的死因,以及犹他州癌症登记处100817名癌症诊断患者的信息。结果PD患者中仅有黑色素瘤和前列腺癌显著高于PD患者;结直肠癌、肺癌、胰腺癌和胃癌均为亏缺。PD患者及其亲属患前列腺癌的风险显著增加。在22 147例前列腺癌患者及其亲属中也发现了PD风险的显著增加。在犹他州PD人群及其亲属中发现患黑色素瘤的风险显著升高。在7841例犹他州黑色素瘤患者及其亲属中发现PD的相对风险显著增加。结论:我们的研究发现了PD与前列腺癌之间的一种新的关联,这种关联延伸到一级、二级和三级亲属。我们还证实了PD患者患黑色素瘤的风险关联;我们扩大了这一发现,包括亲属患病风险的显著增加。这些结果有力地支持了遗传联系。观察到黑色素瘤或前列腺癌患者的亲属患PD的风险增加,这一相互关系进一步加强了这一结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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Archives of neurology
Archives of neurology 医学-临床神经学
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