DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands.

Nicolas Winssinger
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引用次数: 8

Abstract

Over the past decade, several technologies have emerged to access nucleic acid-tagged libraries and select the fittest compound within such libraries. This perspective focuses on recent development with PNA-tagged small molecules displayed on DNA templates for screening purposes and to probe the optimal geometry in multivalent interactions.

rna标记配体的DNA显示:一种多齿配体筛选文库和控制几何形状的通用策略。
在过去的十年中,出现了几种技术来访问核酸标记文库并在这些文库中选择最合适的化合物。这一观点侧重于最近在DNA模板上显示的pna标记小分子的发展,用于筛选目的,并探索多价相互作用中的最佳几何形状。
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