Serum Beta 2-microglobulin/cystatin C index: a useful biomarker in lupus nephritis?

Nephron Extra Pub Date : 2012-01-01 Epub Date: 2012-06-22 DOI:10.1159/000339643

Marcus Vinicius Madureira Silva, Grace T Moscoso-Solorzano, Sonia K Nishida, Gianna Mastroianni-Kirsztajn

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引用次数: 24

Abstract

Background: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease with frequent flares. Our aim was to evaluate the beta 2-microglobulin/cystatin C (β2M/CysC) index versus other markers as a predictor factor for assessment of SLE reactivation.

Methods: We prospectively analyzed 42 patients with lupus nephritis. Disease activity was classified using SLEDAI-2K and BILAG. Routine renal function and laboratory markers of SLE activity were performed, as well as serum β2M (Sβ2M)/serum CysC (SCysC) and Sβ2M/serum creatinine (SCreat) indexes determinations.

Results: The 42 enrolled patients had a mean age of 37.7 ± 13.1 years, 88% were female and 67% Caucasians; mean estimated glomerular filtration rate was 61.9 ± 20.0 ml/min/1.73 m(2). There was a strong correlation between SCreat versus SCysC (r = 0.887), SCreat versus Sβ2M (r = 0.865), and SCysC versus Sβ2M (r = 0.880). Multivariate analysis showed that the Sβ2M/SCreat index is a prognostic factor predicting active lupus nephritis.

Conclusion: As SCysC is a good marker of renal function, it would be expected that the Sβ2M/SCysC index could be a better indicator of renal activity than Sβ2M/SCreat, but in the present study it did not add relevant clinical information in the assessment of renal activity in SLE.

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血清β 2微球蛋白/胱抑素C指数:狼疮性肾炎的有用生物标志物?

背景:系统性红斑狼疮(SLE)是一种慢性多系统自身免疫性疾病，经常发作。我们的目的是评估β2 -微球蛋白/胱抑素C (β2M/CysC)指数与其他标记物作为评估SLE再激活的预测因素。方法:对42例狼疮性肾炎患者进行前瞻性分析。采用SLEDAI-2K和BILAG对疾病活动度进行分类。进行常规肾功能和SLE活动度实验室指标，血清β2M (s - β2M)/血清CysC (SCysC)和s - β2M/血清肌酐(SCreat)指标测定。结果:42例入组患者平均年龄37.7±13.1岁，女性88%，白种人67%;平均估计肾小球滤过率为61.9±20.0 ml/min/1.73 m(2)。SCreat与SCysC (r = 0.887)、SCreat与Sβ2M (r = 0.865)、SCysC与Sβ2M (r = 0.880)有很强的相关性。多因素分析显示Sβ2M/SCreat指数是预测活动性狼疮性肾炎的预后因素。结论:由于SCysC是一个很好的肾功能指标，我们可以预期s - β 2m /SCysC指数可能是一个比s - β 2m /SCreat更好的肾脏活动指标，但在本研究中，它并没有为SLE肾脏活动的评估增加相关的临床信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nephron Extra

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.