Renal evaluation in women with preeclampsia.

Nephron Extra Pub Date : 2012-01-01 Epub Date: 2012-05-22 DOI:10.1159/000338271

T A Facca, G Mastroianni Kirsztajn, A R Pereira, S R Moreira, V P C Teixeira, S K Nishida, N Sass

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Abstract

Background/aims: Preeclampsia (PE) is a cause of glomerulopathy worldwide. Urinary retinol-binding protein (RBP) is a marker of proximal tubular dysfunction, albuminuria is an endothelial injury marker, urine protein:creatinine ratio (PCR) may have a predictive value for renal disease later in life, and, recently, podocyturia has been proposed as a sensitive tool in pregnancy, but it needs to be tested. The aim of this study was to evaluate renal involvement in PE and healthy pregnancy.

Methods: Case-control study with 39 pregnant women assessed after 20 weeks of gestation (25 in the control group, CG, and 14 in the PE group) by performing urinary tests.

Results: Mean (±SD) age and gestational age of the CG were 26.9 ± 6.4 years and 37.1 ± 5.0 weeks, and of the PE group 26.4 ± 6.9 years and 30.6 ± 5.6 weeks, respectively (p = 0.001). Mean (±SD) urinary RBP (p = 0.017), albuminuria (p = 0.002), and urinary albumin concentration (UAC) ratio (p = 0.006) of the CG were 0.4 ± 0.7 mg/l, 7.3 ± 6.9 mg/l, and 8.2 ± 6.7 mg/g and of the PE group 2.0 ± 4.4 mg/l, 2,267.4 ± 2,130.8 mg/l (p = 0.002), and 3,778.9 ± 4,296.6 mg/g (p = 0.006), respectively. Mean (±SD) urine PCR in the PE group was 6.7 ± 6.1 g/g (p < 0.001). No statistical differences were found between podocyturia in the CG and PE group (p = 0.258).

Conclusions: Urinary RBP, PCR, albuminuria, and UAC ratio were elevated in the PE group in comparison to the CG. Podocyturia did not predict PE.

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子痫前期妇女的肾功能评估。

背景/目的：子痫前期（PE）是导致全球肾小球病变的原因之一。尿视黄醇结合蛋白（RBP）是近端肾小管功能障碍的标志物，白蛋白尿是内皮损伤的标志物，尿蛋白：肌酐比值（PCR）可能对日后的肾脏疾病有预测价值，最近，有人提出荚膜尿是妊娠期的一种敏感工具，但还需要进行测试。本研究旨在评估 PE 和健康妊娠的肾脏受累情况：病例对照研究：39 名孕妇在妊娠 20 周后通过尿液检测进行评估（对照组 25 名，CG 组 14 名，PE 组 14 名）：CG组的平均年龄（±SD）为26.9±6.4岁和37.1±5.0周，PE组的平均年龄（±SD）为26.4±6.9岁和30.6±5.6周（P = 0.001）。CG 组的平均（±SD）尿 RBP（p = 0.017）、白蛋白尿（p = 0.002）和尿白蛋白浓度（UAC）比值（p = 0.006）分别为 0.4 ± 0.7 毫克/升、7.3 ± 6.9 mg/l 和 8.2 ± 6.7 mg/g，PE 组分别为 2.0 ± 4.4 mg/l、2,267.4 ± 2,130.8 mg/l (p = 0.002) 和 3,778.9 ± 4,296.6 mg/g (p = 0.006)。PE 组尿液 PCR 平均值（±SD）为 6.7 ± 6.1 g/g（p < 0.001）。CG组和PE组的荚膜尿之间没有统计学差异（P = 0.258）：结论：与 CG 组相比，PE 组的尿 RBP、PCR、白蛋白尿和 UAC 比值均升高。荚膜尿不能预测 PE。

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来源期刊

Nephron Extra

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： An open-access subjournal to Nephron. ''Nephron EXTRA'' publishes additional high-quality articles that cannot be published in the main journal ''Nephron'' due to space limitations.