Distinct patterns of antiamyloid-β antibodies in typical and atypical Alzheimer disease.

Guillaume Dorothée, Michel Bottlaender, Edmond Moukari, Leonardo C de Souza, Renaud Maroy, Fabian Corlier, Olivier Colliot, Marie Chupin, Foudil Lamari, Stephane Lehéricy, Bruno Dubois, Marie Sarazin, Pierre Aucouturier
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引用次数: 26

Abstract

Objective: To compare serum antiamyloid-β (Aβ) antibodies in typical and atypical Alzheimer disease (AD).

Design: Preliminary observations.

Subjects: Thirteen patients with AD, 8 patients with posterior cortical atrophy with evidence of AD (PCA-AD) pathophysiological process by both cerebrospinal fluid (CSF) biomarkers and amyloid imaging, and 12 age-matched control individuals.

Interventions: The class and subclass levels of serum anti-Aβ antibodies were measured using an oligomer-based enzyme-linked immunosorbent assay. This method allowed measuring both free antibodies and, after acidic treatment, the total fraction that includes all antibodies complexed with circulating Aβ40/42 and any cross-reacting antigen.

Results: Anti-Aβ IgG were restricted to the IgG1 and IgG3 subclasses. Their total levels were strikingly lower and more homogeneous in patients with PCA compared with both typical AD and controls, while biomarkers of amyloid deposition (CSF Aβ42 and positron emission tomography amyloid imaging) were similar in patients with AD and patients with PCA.

Conclusions: Serum anti-Aβ IgG1 and IgG3 antibodies differ between distinct forms of AD. Its significance is discussed for possible implications as immune effectors in the specific pathophysiology of AD variants.

典型和非典型阿尔茨海默病中抗淀粉样蛋白β抗体的不同模式
目的:比较典型与非典型阿尔茨海默病(AD)患者血清抗淀粉样蛋白-β (Aβ)抗体水平。设计:初步观察。研究对象:13例AD患者,8例脑脊液(CSF)生物标志物和淀粉样蛋白成像显示有AD (PCA-AD)病理生理过程证据的后皮层萎缩患者,以及12例年龄匹配的对照组。干预措施:使用基于寡聚物的酶联免疫吸附试验测量血清抗a β抗体的类和亚类水平。这种方法既可以测量游离抗体,也可以在酸处理后测量所有抗体与循环Aβ40/42和任何交叉反应抗原络合的总分数。结果:抗β IgG仅限于IgG1和IgG3亚类。与典型AD和对照组相比,PCA患者的总水平明显更低,更均匀,而淀粉样蛋白沉积的生物标志物(CSF Aβ42和正电子发射断层扫描淀粉样蛋白成像)在AD患者和PCA患者中相似。结论:不同类型AD患者血清抗β IgG1和IgG3抗体存在差异。讨论了其作为免疫效应物在AD变异的特定病理生理中的可能意义。
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来源期刊
Archives of neurology
Archives of neurology 医学-临床神经学
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